ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2021
Cortical axonal loss is associated with both gray matter demyelination and white matter tract pathology in progressive multiple sclerosis: Evidence from a combined MRI-histopathology study.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Smoldering neuroinflammation in progressive multiple sclerosis: mechanisms, imaging biomarkers, and therapeutic opportunities.Frontiers in immunology · 2026Review
- Age-impaired remyelination is associated with dysregulated microglial transitions.Nature communications · 2025Article
- A focus on the normal-appearing white and gray matter within the multiple sclerosis brain: a link to smoldering progression.Acta neuropathologica · 2025Review
- Efficient and Rapid Histomorphometry of Regenerating Peripheral Nerve.Muscle & nerve · 2025Article
- Time is myelin: early cortical myelin repair prevents atrophy and clinical progression in multiple sclerosis.Brain : a journal of neurology · 2024Article
- Multimodal MRI study on the relation between WM integrity and connected GM atrophy and its effect on disability in early multiple sclerosis.Journal of neurology · 2024Article
- DNA methylation changes in glial cells of the normal-appearing white matter in Multiple Sclerosis patients.Epigenetics · 2022Article
- Age-dependent gray matter demyelination is associated with leptomeningeal neutrophil accumulation.JCI insight · 2022Article
- Gray matter atrophy in relapsing-remitting multiple sclerosis is associated with white matter lesions in connecting fibers.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Longitudinal analysis of T1w/T2w ratio in patients with multiple sclerosis from first clinical presentation.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Article
- Regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients.Scientific reports · 2021Article
- Applications of dynamic visual acuity test in clinical ophthalmology.International journal of ophthalmology · 2021Review
- Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuroaxonal degeneration is one of the hallmarks of clinical deterioration in progressive multiple sclerosis (PMS).
objectiveTo elucidate the association between neuroaxonal degeneration and both local cortical and connected white matter (WM) tract pathology in PMS.
methods
resultsThe PMS donors displayed significant axonal loss in both demyelinated and normal-appearing (NA) cortices (
conclusionReduced integrity of connected WM tracts and cortical demyelination both contribute to cortical axonal loss in PMS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.