ReviewJournal of the American Heart Association2020
Highly Sensitive Cardiac Troponins: The Evidence Behind Sex-Specific Cutoffs.
Review in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 59 citations in OpenAlex.
- Clinical Gray Zones of Cardiac Troponin Interpretation in the Emergency Department: When Increased Concentrations Do Not Equal Acute Coronary Syndrome.Journal of clinical medicine · 2026Review
- Beyond the ST segment: Multivessel disease and total coronary occlusion in Non-ST segment elevation myocardial infarction patients in Pakistan; A single center retrospective study.Pakistan journal of medical sciences · 2026Article
- Risk factors for cardiac death in women with coronary artery disease.European heart journal open · 2026Article
- Accuracy of Identification of Cardiovascular Events with International Classification of Diseases Diagnosis Codes versus Physician Adjudication in CKD and Kidney Failure.Journal of the American Society of Nephrology : JASN · 2026Article
- Body-Wide Expression Profiles of Commonly Assessed Cardiac Biomarkers in a Large Cohort of Human Tissue Donors.Cardiology · 2026Article
- Plasma cardiovascular stress biomarkers response to marathon running.Sports medicine and health science · 2025Article
- High-Sensitivity Troponins and Homocysteine: Combined Biomarkers for Better Prediction of Cardiovascular Events.International journal of molecular sciences · 2025Review
- Evaluation of sex-specific 0-h high-sensitivity cardiac troponin T thresholds for the risk stratification of non-ST-segment elevation myocardial infarction.Clinical chemistry and laboratory medicine · 2025Article
- Predictive Value of High-Sensitivity Troponin I for Left Ventricular Ejection Fraction in Patients with Non-ST-Elevation Myocardial Infarction.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2025Article
- Influence of Sex and Cardiometabolic Risk Factors on the High-Sensitivity Cardiac Troponins at the Concentrations Used as the Thresholds for Cardiovascular Risk Stratification in a Presumably Healthy Polish Population.Journal of clinical medicine · 2024Article
- High-Sensitivity Troponin: Finding a Meaningful Delta.Journal of cardiovascular development and disease · 2024Review
- A guide to caring for patients who identify as transgender and gender diverse in the emergency department.Journal of the American College of Emergency Physicians open · 2024Article
- Sex Differences in Outcomes of Acute Myocardial Injury After Stroke.Journal of the American Heart Association · 2024Observational
- The Development of a Chest-Pain Protocol for Women Presenting to the Emergency Department.CJC open · 2024Review
- Article
- Article
- Use of high-sensitivity cardiac troponin in the emergency department: A policy resource and education paper (PREP) from the American College of Emergency Physicians.Journal of the American College of Emergency Physicians open · 2023Article
- The Metabolic Pathway of Cardiac Troponins Release: Mechanisms and Diagnostic Role.Cardiology research · 2022Review
- Myocardial injury, troponin release, and cardiomyocyte death in brief ischemia, failure, and ventricular remodeling.American journal of physiology. Heart and circulatory physiology · 2022Review
- Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emergence of various highly sensitive cardiac troponin assays into clinical practice provides a new tool for clinicians diagnosing acute coronary syndrome. These assays also create a challenge for laboratories and clinicians who have yet to familiarize themselves with sex-specific cutoffs. Healthy men and women, studied across various age groups and geographic locations, have notable differences in baseline values of highly sensitive cardiac troponin I and T, leading to establishment of sex-specific upper reference limits and cutoffs. Several differences in cardiac physiology, size, and structure may account for baseline differences in highly sensitive cardiac troponins and outcomes between the sexes. The clinical utility of implementing sex-specific cutoffs for diagnosis and management of acute coronary syndrome remains unclear. Presently, the only prospective study failed to show improved outcomes for men or women with use of sex-specific cutoffs; however, a major limitation is the frequent lack of diagnostic, therapeutic, and preventive interventions prescribed to women with low-level troponin elevations. Based on the current literature, we posit that there may nonetheless be clinical value in the use of sex-specific cutoffs for evaluating suspected acute coronary syndrome, especially in select patient populations such as younger women who tend to have lower baseline values of highly sensitive cardiac troponins. Future studies should prospectively evaluate differences in diagnostic, pharmacologic, and interventional management in men and women using myocardial infarctions classified with sex-specific cutoffs of the highly sensitive cardiac troponin assays.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.