Evidence map›Paper›PMID 32390491›Full record

ArticleJournal of the American Heart Association2020

Pharmacologic TWIK-Related Acid-Sensitive K+ Channel (TASK-1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model.

Felix Wiedmann, Christoph Beyersdorf, Xiaobo Zhou, Antonius Büscher, Manuel Kraft, Jendrik Nietfeld, Teo Puig Walz, Laura A Unger, Axel Loewe, Bastian Schmack and 7 more

Open access · goldAbstract readVideo-Audio Media
In one paragraph

Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Cardiac Manifestations ofHealth science reports · 2026
    Review
  3. Disease mechanism and novel drug therapies for atrial fibrillation.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2025
    Article
  4. Computational modelling of biological systems now and then: revisiting tools and visions from the beginning of the century.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025
    Review
  5. Article
  6. Role of Quercetin in Diabetic Cardiomyopathy.Plants (Basel, Switzerland) · 2024
    Review
  7. Therapeutic advances in atrial fibrillation based on animal models.Journal of Zhejiang University. Science. B · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. 5-(Indol-2-yl)pyrazolo[3,4-Molecules (Basel, Switzerland) · 2021
    Article
  18. Cardiac KHandbook of experimental pharmacology · 2021
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 1 country.

Felix WiedmannDepartment of Cardiology University of Heidelberg Germany.
Christoph BeyersdorfDepartment of Cardiology University of Heidelberg Germany.
Xiaobo ZhouDZHK (German Center for Cardiovascular Research) partner site Heidelberg /Mannheim University of Heidelberg Germany.
Antonius BüscherDepartment of Cardiology University of Heidelberg Germany.
Manuel KraftDepartment of Cardiology University of Heidelberg Germany.
Jendrik NietfeldDepartment of Cardiology University of Heidelberg Germany.
Teo Puig WalzInstitute for Experimental Cardiovascular Medicine University Heart Center Freiburg Bad Krozingen Germany.
Laura A UngerInstitute of Biomedical Engineering Karlsruhe Institute of Technology (KIT) Karlsruhe Germany.
Axel LoeweInstitute of Biomedical Engineering Karlsruhe Institute of Technology (KIT) Karlsruhe Germany.
Bastian SchmackDepartment of Cardiac Surgery University Hospital Heidelberg Germany.
Arjang RuhparwarDepartment of Cardiac Surgery University Hospital Essen Germany.
Matthias KarckDepartment of Cardiac Surgery University Hospital Heidelberg Germany.
Dierk ThomasDepartment of Cardiology University of Heidelberg Germany.
Martin BorggrefeDZHK (German Center for Cardiovascular Research) partner site Heidelberg /Mannheim University of Heidelberg Germany.
Gunnar SeemannInstitute for Experimental Cardiovascular Medicine University Heart Center Freiburg Bad Krozingen Germany.
Hugo A KatusDepartment of Cardiology University of Heidelberg Germany.
Constanze SchmidtDepartment of Cardiology University of Heidelberg Germany.
Heidelberg University · DEGerman Centre for Cardiovascular Research · DEKarlsruhe Institute of Technology · DEUniversitäts-Herzzentrum Freiburg-Bad Krozingen · DEUniversity Hospital Heidelberg · DEEssen University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background The tandem of P domains in a weak inward rectifying K+ channel (TWIK)-related acid-sensitive K

Indexed as

AnimalsAnti-Arrhythmia AgentsAtrial FibrillationDisease Models, AnimalElectrocardiographyElectrophysiologic Techniques, CardiacFemaleHeart RateHumansMaleMembrane PotentialsMolecular Docking SimulationMyocytes, CardiacNerve Tissue Proteinsortho-AminobenzoatesPotassium Channel Blockers2-(butane-1-sulfonylamino)-N-(1-(6-methoxypyridin-3-yl)propyl)benzamideAnti-Arrhythmia AgentsNerve Tissue Proteinsortho-AminobenzoatesPotassium Channel BlockersPotassium Channels, Tandem Pore Domainpotassium channel subfamily K member 3SulfonamidesA293antiarrhythmic pharmacotherapyatrial fibrillationcardioversionK2P3.1TASK‐1

Identifiers

PMID32390491
PMCPMC7660874
OpenAlexW3021387479

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.