Evidence map›Paper›PMID 32390412›Full record

ArticleJournal of the American Chemical Society2020

An Azidoribose Probe to Track Ketoamine Adducts in Histone Ribose Glycation.

Igor Maksimovic, Qingfei Zheng, Marissa N Trujillo, James J Galligan, Yael David

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Biocompatible Chemistry: A Plug-and-Play Toolbox for Chemical Biology Research.Chembiochem : a European journal of chemical biology · 2025
    Review
  3. The chemical language of protein glycation.Nature chemical biology · 2025
    Review
  4. Review
  5. Structural basis for FN3K-mediated protein deglycation.Structure (London, England : 1993) · 2024
    Article
  6. Chemical proteomics approaches for protein post-translational modification studies.Biochimica et biophysica acta. Proteins and proteomics · 2024
    Review
  7. Article
  8. Epigenetic meets metabolism: novel vulnerabilities to fight cancer.Cell communication and signaling : CCS · 2023
    Review
  9. Review
  10. Article
  11. Review
  12. Chromatin structure in cancer.BMC molecular and cell biology · 2022
    Review
  13. Article
  14. Article
  15. Review
  16. A chemical field guide to histone nonenzymatic modifications.Current opinion in chemical biology · 2021
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Igor MaksimovicTri-Institutional PhD Program in Chemical Biology, New York, New York 10065, United States.ORCID 0000-0002-4379-6884
Qingfei ZhengChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.ORCID 0000-0002-8397-3507
Marissa N TrujilloDepartment of Pharmaocology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85721, United States.
James J GalliganDepartment of Pharmaocology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85721, United States.ORCID 0000-0002-5612-0680
Yael DavidTri-Institutional PhD Program in Chemical Biology, New York, New York 10065, United States.ORCID 0000-0003-1696-0025

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI George S Watts · 1994 to 2026
$36.7M
Translating Stress Response Targeted Therapy for B-Cell LymphomasP50CA192937 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI DALLA-FAVERA, RICCARDO, ZELENETZ, ANDREW D. · 2016 to 2020
$10.9M
Training in Environmental Toxicology of Human DiseaseT32ES007091 · NIEHS · UNIVERSITY OF ARIZONA · PI Nathan J Cherrington · 1985 to 2026
$10.7M
Investigating histone glycation as a new dynamic epigenetic markR35GM138386 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI DAVID-SHTERNBERG, YAEL E · 2020 to 2024
$2.2M
Application of intein-based chemical methods to directly manipulate neuronal histone modifications in rodent models of addictionR21DA044767 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAVID-SHTERNBERG, YAEL E, MAZE, IAN S. · 2018 to 2019
$444k
NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA192937NIDA NIH HHS R21 DA044767NIEHS NIH HHS P30 ES006694NIEHS NIH HHS T32 ES007091NIGMS NIH HHS R35 GM138386
6 · The paper itself

Abstract

Reactive cellular metabolites can modify macromolecules and form adducts known as nonenzymatic covalent modifications (NECMs). The dissection of the mechanisms, regulation, and consequences of NECMs, such as glycation, has been challenging due to the complex and often ambiguous nature of the adducts formed. Specific chemical tools are required to directly track the formation of these modifications on key targets in order to uncover their underlying physiological importance. Here, we present the novel chemoenzymatic synthesis of an active azido-modified ribose analog, 5-azidoribose (

Indexed as

AzidesGlycosylationHistonesMolecular StructureRiboseAzidesHistonesRibose

Identifiers

PMID32390412
PMCPMC8052992

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.