Observational studyThe oncologist2020
Prolonged Opioid Use After Surgery for Early-Stage Breast Cancer.
Observational study in The oncologist, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Feasibility of Prospectively Comparing Opioid Analgesia With Opioid-Free Analgesia After Outpatient General Surgery: A Pilot Randomized Clinical Trial.JAMA network open · 2022Trial
- Opioid use after breast cancer in Denmark: a nationwide study of social and clinical factors.Journal of the National Cancer Institute · 2026Article
- Article
- Clinical Efficacy of Erector Spinae Plane Block for Pain Management After Breast Surgeries: A Narrative Review.Current pain and headache reports · 2025Review
- Comparative effectiveness of opioid versus opioid-free analgesia after outpatient breast surgery: PAIN-Alt trial protocol.BMJ open · 2025Article
- Opioid prescription and usage disparities among Puerto Rican breast cancer survivors: findings from the Puerto Rico central cancer registry-health insurance linkage database (PRCCR-HILD).Cancer causes & control : CCC · 2025Article
- Article
- Article
- Opioid prescriptions at the point of surgery, bone metastasis, or death among patients with breast cancer in Japanese acute care hospitals: a claims-based, retrospective, longitudinal study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Postdischarge Nausea and Vomiting and Co-occurring Symptoms in Women Following Breast Cancer Surgery.Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses · 2023Observational
- The association between perioperative opioids and breast cancer recurrence: a narrative review of the literature.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2023Review
- Prolonged Opioid Use Among Opioid-Naive Women Undergoing Breast Reconstructive Surgery.Archives of plastic surgery · 2022Article
- Trends and patterns in the use of opioids among metastatic breast cancer patients.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
introductionThis study examined the patterns of prolonged opioid use and the factors associated with higher risk of prolonged opioid use among opioid-naïve working-age patients with early-stage breast cancer.
methodsUsing MarketScan data, the study identified 23,440 opioid-naïve patients who received surgery for breast cancer between January 2000 and December 2014 and filled at least one opioid prescription attributable to surgery. Prolonged opioid use was defined as one or more prescriptions for opioids within 90 to 180 days after surgery and defined extra-prolonged opioid use as one or more opioid prescriptions between 181 and 365 days after surgery. Multivariable logistic regressions were performed to ascertain factors associated with prolonged and extra-prolonged use of opioids.
findingsOf the 23,440 patients, 4,233 (18%) had prolonged opioid use, and 2,052 (9%) had extra-prolonged opioid use. Patients who received mastectomy plus reconstruction had the highest rate of prolonged opioid use (38%) followed by mastectomy alone (15%). A multivariable logistic regression confirmed that patients with mastectomy and reconstruction had the highest odds ratio of prolonged opioid use compared to lumpectomy and whole breast irradiation (adjusted odds ratio, 5.6; 95% confidence interval, 5.1-6.1). Mean daily opioid dose was consistently high without any obvious dosage reduction among patients with opioid use.
interpretationThis large observational study showed a high rate of prolonged opioid use among patients who received surgery for early-stage breast cancer and found significant difference in prolonged opioid use by treatment type. IMPLICATIONS FOR PRACTICE: This large observational study found a high rate of prolonged opioid use among working-age patients with early-stage breast cancer who received curative surgery, especially among patients who received mastectomy. Among patients with opioid use, the mean daily opioid dose was consistently high without any obvious dosage tapering. This study highlights the need to emphasize appropriate opioid therapy and potential dosage reduction or discontinuation among patients with early-stage breast cancer who received surgical interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.