SynthesisOral diseases2021
Using next-generation sequencing to detect oral microbiome change following periodontal interventions: A systematic review.
Synthesis in Oral diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Using next-generation sequencing to detect oral microbiome change following periodontal interventions: A systematic review.Oral diseases · 2021Pooled it
- Nd: YAG laser-assisted treatment of subgingival microbiota composition in stage III-IV periodontitis: a randomized controlled study.Clinical oral investigations · 2026Trial
- Oral Microbiome Signatures in Indonesian Healthy, Gingivitis, and Periodontitis Subjects: A 16S rRNA Next-Generation Sequencing Analysis-Based Exploratory Study.Dentistry journal · 2026Article
- Evaluation of the antimicrobial effect of cannabidiol (CBD) in a multispecies subgingival biofilm model.Journal of oral microbiology · 2026Article
- Next-Generation Sequencing Insights into the Oral Microbiome and Antibiotic Resistance Genes in Grey Wolves (Animals : an open access journal from MDPI · 2025Article
- Integrative insights into the oral microbiome's role in systemic diseases: novel therapeutic strategies and future directions.Antonie van Leeuwenhoek · 2025Review
- Measuring the Invisible: Microbial Diagnostics for Periodontitis-A Narrative Review.International journal of molecular sciences · 2025Review
- Association Between Periodontal Pathogens and Inflammation in Patients with Acute Coronary Syndromes.International journal of molecular sciences · 2025Article
- Quantifying periodontitis-associated oral dysbiosis in tongue and saliva microbiomes-An integrated data analysis.Journal of periodontology · 2025Article
- The Oral Microbiome in Diabetes, Arterial Hypertension, and Obesity: A Scoping Review.Advances in experimental medicine and biology · 2025Article
- Characteristics of the oral microbiome in youth exposed to caregiving adversity.Brain, behavior, & immunity - health · 2024Article
- Oral Microbiome: A Review of Its Impact on Oral and Systemic Health.Microorganisms · 2024Review
- Exploring oral bacterial compositional network in two oral disease groups using a convergent approach of NGS-molecular diagnostics.Genes & genomics · 2024Article
- Longitudinal Microbiome Changes in Supragingival Biofilm Transcriptomes Induced by Orthodontics.JDR clinical and translational research · 2024Article
- Impact of Pericoronary Microbiota Composition on Course of Recovery after Third Molar Alveotomy.Life (Basel, Switzerland) · 2024Article
- Effect of mobile app-based oral hygiene instructions on clinical parameters, oral bacterial diversity, and composition of subgingival microbiota in periodontitis patients.Journal of oral microbiology · 2024Article
- Letter to the Editor, "Advancements and Challenges in Precision Dentistry".Frontiers in dentistry · 2024Article
- Oral and fecal microbiota perturbance in cocaine users: Can rTMS-induced cocaine abstinence support eubiosis restoration?iScience · 2023Article
- Effect of Antibiotic Eye Drops on the Nasal Microbiome in Healthy Subjects-A Pilot Study.Antibiotics (Basel, Switzerland) · 2023Article
- A Reciprocal Link between Oral, Gut Microbiota during Periodontitis: The Potential Role of Probiotics in Reducing Dysbiosis-Induced Inflammation.International journal of molecular sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectivesThis systematic review was to evaluate the change of oral microbiome based on next-generation sequencing (NGS)-metagenomic analysis following periodontal interventions among systematically healthy subjects. MATERIALS AND
methodsA structured search strategy consisting of "metagenomics" and "oral diseases" was applied to PubMed, EMBASE, and Web of Science to identify effective papers. The included studies were original studies published in English, using metagenomic approach to analyze the effectiveness of periodontal intervention on oral microbiome among systematically healthy human subjects with periodontitis.
resultsA total of 12 papers were included in this review. Due to the heterogeneity of selected study, quantitative analysis was not performed. The findings as to how alpha diversity changed after interventions were not consistent across studies. Six studies illustrated clear separation of microbial composition between dental plaque samples collected before and after intervention using principal coordinates/component analysis. The most commonly detected genera before intervention were Porphyromonas, Treponema, Tannerella, and Prevotella, while Streptococcus and Actinomyces usually increased and became the dominant genera after intervention. Correlation network analysis revealed that after intervention, the topology of network was different compared to the corresponding pre-interventional samples.
conclusionExisting evidence of metagenomic studies depicts a complex change in oral microbiome after periodontal intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.