Evidence map›Paper›PMID 32390135›Full record

ArticleEuropean journal of immunology2020

IL-7 induces sCD127 release and mCD127 downregulation in human CD8

Sandra C Côté, Stephanie C Burke Schinkel, Tamara K Berthoud, Priscila O Barros, Maria Sanchez-Vidales, April M Davidson, Angela M Crawley, Jonathan B Angel

Open access · hybridAbstract read
In one paragraph

Article in European journal of immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Immuno-cell metabolic changes in HIV-1 infection.Infectious diseases & immunity · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sandra C CôtéThe Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Stephanie C Burke SchinkelThe Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Tamara K BerthoudThe Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Priscila O BarrosThe Ottawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0000-0002-6173-0416
Maria Sanchez-VidalesThe Ottawa Hospital Research Institute, Ottawa, ON, Canada.
April M DavidsonThe Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Angela M CrawleyThe Ottawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0000-0002-7453-7922
Jonathan B AngelThe Ottawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0000-0003-3102-4462
University of Ottawa · CAOttawa Hospital · CA

Funding

CIHR HOP-98830
6 · The paper itself

Abstract

The IL-7 receptor specific α chain, CD127, can be expressed both as a membrane-associated (mCD127) and a soluble form (sCD127), however, the mechanisms involved in their regulation remain to be defined. We first demonstrated in primary human CD8

Indexed as

Antiretroviral Therapy, Highly ActiveCD8-Positive T-LymphocytesCells, CulturedDown-RegulationHIV-1HIV InfectionsHumansInterleukin-7Interleukin-7 Receptor alpha SubunitJanus KinasesMatrix Metalloproteinase 9Phosphatidylinositol 3-KinasesReceptors, Interleukin-7Signal TransductionSTAT5 Transcription FactorInterleukin-7Interleukin-7 Receptor alpha SubunitJanus KinasesMatrix Metalloproteinase 9Phosphatidylinositol 3-KinasesReceptors, Interleukin-7STAT5 Transcription FactorCD127CD8+ T cellsHAARTHIVIL-7

Identifiers

PMID32390135
PMCPMC7586945
OpenAlexW3022122473

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.