Evidence map›Paper›PMID 32390091›Full record

ArticleInfection2020

Clinical characteristics of 194 cases of COVID-19 in Huanggang and Taian, China.

Hong Zhang, Wenli Shang, Qinghua Liu, Xuejing Zhang, Maochuan Zheng, Maokui Yue

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 5 pooled it
0.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 5 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  4. Antibiotic prescribing in patients with COVID-19: rapid review and meta-analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2021
    Pooled it
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  6. Article
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  8. COVID-19 in Elderly Patients: Risk Factors for Disease Severity.Infectious diseases & clinical microbiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hong Zhang *Department of Hematopathology, The Second Affiliated Hospital of Shandong First Medical University, Taian, 271000, China.
Wenli Shang *Department of Critical Care Medicine, The Second Affiliated Hospital of Shandong First Medical University, No. 706 Taishan Road, Taian, 271000, China.
Qinghua LiuDepartment of Clinical Laboratory, The Second Affiliated Hospital of Shandong First Medical University, Taian, 271000, China.
Xuejing ZhangTaian Daiyue Maternal and Child Care Service Centre, Taian, 271000, China.
Maochuan ZhengDepartment of Critical Care Medicine, The Second Affiliated Hospital of Shandong First Medical University, No. 706 Taishan Road, Taian, 271000, China.
Maokui YueDepartment of Critical Care Medicine, The Second Affiliated Hospital of Shandong First Medical University, No. 706 Taishan Road, Taian, 271000, China. maokuiyue@126.com.
Shandong First Medical University · CNAffiliated Hospital of Taishan Medical University · CN

Funding

The Project of COVID-19 of Taian, Shandong Province COVID-19-2020
6 · The paper itself

Abstract

purposeWe aimed to report the clinical characteristics of 194 cases coronavirus disease-19 (COVID-19) in Huanggang, Hubei and Taian, Shandong.

methodsWe retrospectively investigated the clinical, laboratory characteristics and CT imaging of confirmed cases of COVID-19 from January 22 to February 28, 2020 in Huanggang Central Hospital and The Second Affiliated Hospital of Shandong First Medical University. Real time PCR was used to detect the new coronavirus in respiratory samples. Immunohistochemical staining was used to detect the expressions of ACE2 in tissues.

resultsAmong the 194 patients infected with COVID-19, 108 patients were male, with a median age of 48.3 years. The average preclinical period was 7.44 day. Except for 37 severe or critically ill patients, the rest of the 157 patients exhibited mild or moderate symptoms. 190 (97.94%) patients were confirmed during the three times nucleic acid test. The main clinical symptom of the patients were fever, sore throat and cough, which accounted for 146 cases (75.26%), 98 (50.52%) and 86 cases (44.33%), respectively. 30 patients (15.46%) showed liver dysfunction. Imaging examination showed that 141 patients (72.68%) showed abnormal density shadow, while 53 cases (27.32%) had no obvious abnormality in the parenchyma of both lungs. Up to now, 109 cases have been discharged from the hospital, and 9 patients died. The ACE2 expression levels were up-regulated in patients of severe type and critically ill type.

conclusionClinical symptoms, laboratory tests and CT imaging should be combined for comprehensive analysis to diagnose COVID-19. ACE2 may be the receptor of COVID-19.

Indexed as

AdolescentAdultAgedAngiotensin-Converting Enzyme 2BetacoronavirusBiomarkersChinaClinical Laboratory TechniquesCoronavirus InfectionsCoughCOVID-19COVID-19 TestingFemaleFeverGene ExpressionHumansACE2 protein, humanAngiotensin-Converting Enzyme 2BiomarkersPeptidyl-Dipeptidase AACE2Clinical characteristicsCoronavirus disease-19 (COVID-19)HuanggangNovel coronavirus pneumoniaTaian

Identifiers

PMID32390091
PMCPMC7211492
OpenAlexW3022704124

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.