ArticleCerebral cortex (New York, N.Y. : 1991)2020
Noradrenergic But Not Dopaminergic Neurons Signal Task State Changes and Predict Reengagement After a Failure.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes.PLoS computational biology · 2022Trial
- Effort Mobilization and Lapses of Sustained Attention.Cognitive, affective & behavioral neuroscience · 2022Trial
- Orbitofrontal noradrenaline supports adaptive learning-rate adjustment in probabilistic reversal learning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The role of the locus coeruleus in eye movements during perceptual decision making.bioRxiv : the preprint server for biology · 2026Article
- Mobilizing effort to reduce lapses of sustained attention: examining the effects of content-free cues, feedback, and points.Cognitive, affective & behavioral neuroscience · 2025Article
- Effects of Adult Age and Functioning of the Locus Coeruleus Norepinephrinergic System on Reward-Based Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Noradrenergic Modulation of Learned and Innate Behaviors in Dopamine Transporter Knockout Rats by Guanfacine.Biomedicines · 2023Article
- Natural locus coeruleus dynamics during feeding.Science advances · 2022Article
- Locus coeruleus neurons encode the subjective difficulty of triggering and executing actions.PLoS biology · 2021Article
- The ascending arousal system shapes neural dynamics to mediate awareness of cognitive states.Nature communications · 2021Article
- Locus Coeruleus Norepinephrine in Learned Behavior: Anatomical Modularity and Spatiotemporal Integration in Targets.Frontiers in neural circuits · 2021Review
- Roles of Motor Cortex Neuron Classes in Reach-Related Modulation for Hemiparkinsonian Rats.Frontiers in neuroscience · 2021Article
- Locus coeruleus-norepinephrine: basic functions and insights into Parkinson's disease.Neural regeneration research · 2020Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The two catecholamines, noradrenaline and dopamine, have been shown to play comparable roles in behavior. Both noradrenergic and dopaminergic neurons respond to cues predicting reward availability and novelty. However, even though both are thought to be involved in motivating actions, their roles in motivation have seldom been directly compared. We therefore examined the activity of putative noradrenergic neurons in the locus coeruleus and putative midbrain dopaminergic neurons in monkeys cued to perform effortful actions for rewards. The activity in both regions correlated with engagement with a presented option. By contrast, only noradrenaline neurons were also (i) predictive of engagement in a subsequent trial following a failure to engage and (ii) more strongly activated in nonrepeated trials, when cues indicated a new task condition. This suggests that while both catecholaminergic neurons are involved in promoting action, noradrenergic neurons are sensitive to task state changes, and their influence on behavior extends beyond the immediately rewarded action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.