Evidence map›Paper›PMID 32390042›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2020

Prefrontal Multielectrode Transcranial Direct Current Stimulation Modulates Performance and Neural Activity Serving Visuospatial Processing.

Yasra Arif, Rachel K Spooner, Alex I Wiesman, Amy L Proskovec, Michael T Rezich, Elizabeth Heinrichs-Graham, Tony W Wilson

Open access · bronzeAbstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yasra ArifDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Rachel K SpoonerDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Alex I WiesmanDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Amy L ProskovecCenter for Magnetoencephalography, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Michael T RezichDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Elizabeth Heinrichs-GrahamDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Tony W WilsonDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.
University of Nebraska Medical Center · USUniversity of Nebraska at Omaha · US

Funding

Translational Imaging and Behavioral Assessment (TIBA) CoreP20GM130447 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI David E Warren · 2020 to 2026
$20.7M
MULTIMODAL IMAGING OF NEUROHIV DYNAMICS (MIND): AN OMAHA-PITTSBURGH CONSORTIUMR01MH118013 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WILSON, TONY W · 2018 to 2022
$4.9M
THE PROGRESSIVE ELEVATION OF SPONTANEOUS CORTICAL ACTIVITY IN HAND (PESCAH) PROJECTR01MH116782 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WILSON, TONY W · 2018 to 2022
$3.4M
Neurophysiological markers of HAND and the impact of aging: Evidence from MEGR01MH103220 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WILSON, TONY W · 2014 to 2018
$2.5M
THE IMPACT OF SPONTANEOUS CORTICAL ACTIVITY ON NEURAL OSCILLATIONS AND BEHAVIORAL PERFORMANCE: EVIDENCE FROM HIGH-DEFINITION TDCS AND MEGRF1MH117032 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WILSON, TONY W · 2018 to 2018
$2.4M
Neuroimmunology of Disease Training ProgramT32NS105594 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Aditya N Bade, Howard E Gendelman · 2018 to 2026
$1.4M
Oscillatory markers of cognitive deficits in patients with Alzheimer's diseaseF31AG055332 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WIESMAN, ALEX I · 2017 to 2019
$119k
NIA NIH HHS F31 AG055332NIGMS NIH HHS P20 GM130447NIMH NIH HHS R01 MH103220NIMH NIH HHS R01 MH116782NIMH NIH HHS RF1 MH117032NINDS NIH HHS T32 NS105594
6 · The paper itself

Abstract

The dorsolateral prefrontal cortex (DLPFC) is known to play a critical role in visuospatial attention and processing, but the relative contribution of the left versus right DLPFC remains poorly understood. We applied multielectrode transcranial direct-current stimulation (ME-tDCS) to the left and right DLPFC to investigate its net impact on behavioral performance and population-level neural activity. The primary hypothesis was that significant laterality effects would be observed in regard to behavior and neural oscillations. Twenty-five healthy adults underwent three visits (left, right, and sham ME-tDCS). Following stimulation, participants completed a visuospatial processing task during magnetoencephalography (MEG). Statistically significant oscillatory events were imaged, and time series were then extracted from the peak voxels of each response. Behavioral findings indicated differences in reaction time and accuracy, with left DLPFC stimulation being associated with slower responses and decreased accuracy compared to right stimulation. Left DLPFC stimulation was also associated with increases in spontaneous theta and decreases in gamma within occipital cortices relative to both right and sham stimulation, while connectivity among DLPFC and visual cortices was generally increased contralateral to stimulation. These data suggest spectrally specific modulation of spontaneous cortical activity at the network-level by ME-tDCS, with distinct outcomes based on the laterality of stimulation.

Indexed as

AdultAttentionDorsolateral Prefrontal CortexFemaleFunctional LateralityHumansMagnetoencephalographyMaleTranscranial Direct Current Stimulationlaterality effectsmagnetoencephalographyneural oscillationsspontaneous activity

Identifiers

PMID32390042
PMCPMC7391278
OpenAlexW3022364578

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.