Evidence map›Paper›PMID 32389888›Full record

ArticleOphthalmology. Retina2020

Correlation of Quantitative Measurements with Diabetic Disease Severity Using Multiple En Face OCT Angiography Image Averaging.

Jesse J Jung, Daryle Jason G Yu, Anne Zeng, Michael H Chen, Yue Shi, Marco Nassisi, Kenneth M Marion, Srinivas R Sadda, Quan V Hoang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology. Retina, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jesse J JungEast Bay Retina Consultants, Inc, Oakland, California; Department of Ophthalmology, University of California, San Francisco, San Francisco, California. Electronic address: jung.jesse@gmail.com.
Daryle Jason G YuSingapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS Medical School, Singapore, Republic of Singapore.
Anne ZengEast Bay Retina Consultants, Inc, Oakland, California.
Michael H ChenSilicon Valley Eyecare, Santa Clara, California.
Yue ShiDoheny Eye Institute, Los Angeles, California.
Marco NassisiDoheny Eye Institute, Los Angeles, California; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Kenneth M MarionDoheny Eye Institute, Los Angeles, California.
Srinivas R SaddaDoheny Eye Institute, Los Angeles, California; Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Quan V HoangSingapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS Medical School, Singapore, Republic of Singapore; Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, New York.

Funding

Novel Approaches in the Therapy of Pathologic MyopiaK08EY023595 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HOANG, QUAN VAN MANH · 2014 to 2017
$865k
NEI NIH HHS K08 EY023595
6 · The paper itself

Abstract

purposeTo evaluate the effect of averaging en face OCT angiography (OCTA) images on quantitative measurements of the retinal microvasculature and their correlation to diabetic retinopathy (DR) disease severity.

designCross-sectional cohort study.

participantsOne hundred five eyes (65 patients) comprising 28 eyes from 19 healthy, aged-matched control participants, 14 eyes from 9 diabetics without DR, and 63 eyes from 37 diabetics with varying levels of DR.

methodsSpectral-domain CIRRUS 5000 (Carl Zeiss Meditec, Dublin, CA) OCTA images with no macular edema or significant motion artifact were acquired 5 times with the 3 × 3-mm scan pattern. En face images of the superficial retinal layer (SRL) and deep retinal layer were registered and averaged. Vessel length density (VLD), perfusion density (PD), and foveal avascular zone (FAZ) parameters were measured on averaged versus single OCTA images.

main outcome measuresUnivariate and multivariate linear regression correlated quantitative metrics to DR severity and best-corrected visual acuity (BCVA).

resultsEighty-four eyes (55 patients) met the inclusion criteria. Almost uniformly, lower VLD and PD parameters were associated significantly with worse DR severity and BCVA. Multivariate linear regression for DR severity resulted in an R

conclusionsAveraging of en face OCTA images improves the visualization of capillaries, particularly increasing the clarity of the FAZ borders, and therefore improves the correlation of vessel density and FAZ-specific parameters to DR severity and BCVA.

Indexed as

Visual AcuityCross-Sectional StudiesDiabetic RetinopathyFemaleFluorescein AngiographyFollow-Up StudiesFundus OculiHumansMacula LuteaMaleMiddle AgedRetinal VesselsRetrospective StudiesSeverity of Illness IndexTomography, Optical Coherence

Identifiers

PMID32389888
PMCPMC7609623

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.