ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2020
Acute Posttrauma Resting-State Functional Connectivity of Periaqueductal Gray Prospectively Predicts Posttraumatic Stress Disorder Symptoms.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 18 citations in OpenAlex.
- Dissociable Neural Responses to Conditioned Social Threats are Modulated by Spatial Proximity in PTSD and MDD.bioRxiv : the preprint server for biology · 2026Article
- Brain State Dynamics in Ketamine-Induced Dissociation Resemble Those in Posttraumatic Stress Disorder.Biological psychiatry global open science · 2026Article
- Differential brainstem connectivity according to sex and menopausal status in healthy male and female individuals.Biology of sex differences · 2025Article
- [Inhibition of glutamatergic neurons in the dorsomedial periaqueductal gray alleviates excessive defensive behaviors of mice with post-traumatic stress disorder].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- The contribution of periaqueductal gray in the regulation of physiological and pathological behaviors.Frontiers in neuroscience · 2024Review
- Sex-dependent risk factors for PTSD: a prospective structural MRI study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Subfornical organ interleukin 1 receptor: A novel regulator of spontaneous and conditioned fear associated behaviors in mice.Brain, behavior, and immunity · 2022Article
- Understanding Pain and Trauma Symptoms in Veterans From Resting-State Connectivity: Unsupervised Modeling.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Contrasting Associations Between Heart Rate Variability and Brainstem-Limbic Connectivity in Posttraumatic Stress Disorder and Its Dissociative Subtype: A Pilot Study.Frontiers in behavioral neuroscience · 2022Article
- Neural contributors to trauma resilience: a review of longitudinal neuroimaging studies.Translational psychiatry · 2021Review
- Moral wounds run deep: exaggerated midbrain functional network connectivity across the default mode network in posttraumatic stress disorder.Journal of psychiatry & neuroscience : JPNArticle
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7 authors at 5 institutions in 1 country.
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Abstract
backgroundPosttraumatic stress disorder (PTSD) is characterized by hyperarousal, avoidance, and intrusive/re-experiencing symptoms. The periaqueductal gray (PAG), which generates behavioral responses to physical and psychological stressors, is also implicated in threat processing. Distinct regions of the PAG elicit opposing responses to threatening or stressful stimuli; the ventrolateral PAG evokes passive coping strategies (e.g., analgesia), whereas the dorsolateral PAG (dlPAG) promotes active responses (e.g., fight or flight). We investigated whether altered PAG resting-state functional connectivity (RSFC) prospectively predicted PTSD symptoms.
methodsA total of 48 trauma-exposed individuals underwent an RSFC scan 2 weeks posttraumatic injury. Self-report measures, including the visual analog scale for pain and the Impact of Event Scale, were collected at 2 weeks and 6 months posttrauma. We analyzed whether acute bilateral PAG RSFC was a marker of risk for total 6-month symptom severity and specific symptom clusters. In an exploratory analysis, we investigated whether dlPAG RSFC predicted PTSD symptoms.
resultsAfter adjusting for physical pain ratings, greater acute posttrauma PAG-frontal pole and PAG-posterior cingulate cortex connectivity was positively associated with 6-month total PTSD symptoms. Weaker dlPAG-superior/inferior parietal lobule connectivity predicted both higher hyperarousal and higher intrusive symptoms, while weaker dlPAG-supramarginal gyrus RSFC was associated with only hyperarousal symptoms.
conclusionsAltered connectivity of the PAG 2 weeks posttrauma prospectively predicted PTSD symptoms. These findings suggest that aberrant PAG function may serve as a marker of risk for chronic PTSD symptoms, possibly by driving specific symptom clusters, and more broadly that connectivity of specific brain regions may underlie specific symptom profiles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.