Evidence map›Paper›PMID 32389733›Full record

ArticleAntiviral research2020

Identification of potassium and calcium channel inhibitors as modulators of polyomavirus endosomal trafficking.

Samuel J Dobson, Jamel Mankouri, Adrian Whitehouse

Open access · hybridAbstract read
In one paragraph

Article in Antiviral research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Modulation ofJournal of natural products · 2023
    Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Repurposing calcium channel blockers as antiviral drugs.Journal of cell communication and signaling · 2020
    Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Samuel J DobsonSchool of Molecular and Cellular Biology, Faculty of Biological Sciences, United Kingdom.
Jamel MankouriSchool of Molecular and Cellular Biology, Faculty of Biological Sciences, United Kingdom; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom. Electronic address: j.mankouri@leeds.ac.uk.
Adrian WhitehouseSchool of Molecular and Cellular Biology, Faculty of Biological Sciences, United Kingdom; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom. Electronic address: a.whitehouse@leeds.ac.uk.
University of Leeds · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During virus entry, members of the Polyomaviridae transit the endolysosomal network en route to the endoplasmic reticulum (ER), from which degraded capsids escape into the cytoplasm and enter the nucleus. Emerging evidence suggests that viruses require both endosomal acidification and the correct ionic balance of K

Indexed as

AnimalsBenzylisoquinolinesCalcium Channel BlockersCell LineCell MovementChlorocebus aethiopsDrug DiscoveryEndosomesHEK293 CellsHumansMerkel cell polyomavirusPolyomavirusPotassium Channel BlockersSimian virus 40VerapamilVero CellsBenzylisoquinolinesCalcium Channel BlockersPotassium Channel BlockerstetrandrineVerapamilEndosomal fusionIon channelsPolyomavirusTetrandrineTwo pore channelVerapamil

Identifiers

PMID32389733
PMCPMC7205714
OpenAlexW3023544591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.