Evidence map›Paper›PMID 32389572›Full record

ArticleThe American journal of pathology2020

CD4

Thi Hong Khanh Vu, Huihui Chen, Li Pan, Kin-Sang Cho, Djoeke Doesburg, Eric F Thee, Nan Wu, Elisa Arlotti, Martine J Jager, Dong Feng Chen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 32 citations in OpenAlex.

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  20. Visual deficits after traumatic brain injury.Histology and histopathology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 4 countries.

Thi Hong Khanh VuSchepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands.
Huihui ChenSchepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Li PanSchepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.
Kin-Sang ChoSchepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; Geriatric Research Education and Clinical Center, Office of Research and Development, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, Massachusetts.
Djoeke DoesburgSchepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands.
Eric F TheeSchepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands.
Nan WuSchepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology, Southwest Eye Hospital, Southwest Hospital, Third Military Medical University, Chongqing, China.
Elisa ArlottiSchepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands.
Martine J JagerDepartment of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands.
Dong Feng ChenSchepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts. Electronic address: dongfeng_chen@meei.harvard.edu.
Massachusetts Eye and Ear Infirmary · USLeiden University Medical Center · NL

Funding

VISION RESEARCHP30EY003790 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Patricia Ann D'Amore · 1985 to 2026
$25.5M
The Molecular Basis Underlying Optic Nerve Growth in Development and RegenerationR01EY025259 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI CHEN, DONG FENG · 2016 to 2020
$3.2M
Development of a Next Generation Visual Performance Assessment System for RodentsR44EY025913 · NEI · AFASCI, INC. · PI CHEN, DONG FENG, LUO, GANG · 2019 to 2020
$1.5M
A Visual Assessment System for Retinal Function/Drug DiscoveryR41EY025913 · NEI · AFASCI, INC. · PI CHEN, DONG FENG, LUO, GANG · 2015 to 2015
$233k
NEI NIH HHS P30 EY003790NEI NIH HHS R01 EY025259NEI NIH HHS R41 EY025913NEI NIH HHS R44 EY025913
6 · The paper itself

Abstract

Retinal ischemic events, which result from occlusion of the ocular vasculature share similar causes as those for central nervous system stroke and are among the most common cause of acute and irreversible vision loss in elderly patients. Currently, there is no established treatment, and the condition often leaves patients with seriously impaired vision or blindness. The immune system, particularly T-cell-mediated responses, is thought to be intricately involved, but the exact roles remain elusive. We found that acute ischemia-reperfusion injury to the retina induced a prolonged phase of retinal ganglion cell loss that continued to progress during 8 weeks after the procedure. This phase was accompanied by microglial activation and CD4

Indexed as

Adoptive TransferAnimalsCD4-Positive T-LymphocytesDisease Models, AnimalDisease ProgressionIschemiaMiceRetinaRetinal DegenerationRetinal DiseasesRetinal Ganglion CellsRetinal Vessels

Identifiers

PMID32389572
PMCPMC7397460
OpenAlexW3021933852

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.