Observational studyAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2020
Adiposity, Sex, and Cardiovascular Disease Risk in Children With CKD: A Longitudinal Study of Youth Enrolled in the Chronic Kidney Disease in Children (CKiD) Study.
Observational study in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00327860 (Chronic Kidney Disease in Children Prospective Cohort Study), which is not on this map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)
Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Patient-reported measures in children and adolescents with chronic kidney disease and their validation: A scoping review.Pediatric nephrology (Berlin, Germany) · 2026Article
- Lower blood pressure targets in childhood chronic kidney disease.Translational pediatrics · 2025Article
- Framework for Kidney Health Follow-Up Among Neonates With Critical Cardiac Disease: A Report From the Neonatal Kidney Health Consensus Workshop.Journal of the American Heart Association · 2025Review
- Growth hormone in pediatric chronic kidney disease: more than just height.Pediatric nephrology (Berlin, Germany) · 2024Review
- Hypertension and Cardiovascular Risk Among Children with Chronic Kidney Disease.Current hypertension reports · 2024Review
- Evaluation of cardiac remodeling in pediatric chronic kidney disease by cardiovascular magnetic resonance.BMC cardiovascular disorders · 2024Article
- Changes in the cardiovascular risk profile in children approaching kidney replacement therapy.EClinicalMedicine · 2024Article
- Positive Correlation between BMI and Left Ventricle and Atrium Inside Diameter Size in Chinese Type 2 Diabetes Patients with Left Ventricular and Atrial Enlargement.Reviews in cardiovascular medicine · 2024Article
- Sex difference in nocturnal blood pressure dipping in adolescents with varying degrees of adiposity.BMC pediatrics · 2024Article
- Role of Nutrients in Pediatric Non-Dialysis Chronic Kidney Disease: From Pathogenesis to Correct Supplementation.Biomedicines · 2024Review
- Longitudinal changes of health-related quality of life in childhood chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2023Article
- Anthropometric measures and patient outcome in pediatric chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2023Article
- Associations of longitudinal height and weight with clinical outcomes in pediatric kidney replacement therapy: results from the ESPN/ERA Registry.Pediatric nephrology (Berlin, Germany) · 2023Article
- Triglyceride glucose-body mass index and cardiovascular mortality in patients undergoing peritoneal dialysis: a retrospective cohort study.Lipids in health and disease · 2023Article
- Association of Childhood Blood Pressure with Left Atrial Size and Function: Study of High Blood Pressure in Pediatrics-Adult Hypertension in Youth (SHIP AHOY).The Journal of pediatrics · 2023Article
- Malnutrition Patterns in Children with Chronic Kidney Disease.Life (Basel, Switzerland) · 2023Review
- Cardiometabolic Risk Factors in Pediatric Kidney Transplant Recipients.Turkish archives of pediatrics · 2023Article
- Article
- Adipokines as predictive factor of cardiac function in pediatric patients with chronic kidney disease.Frontiers in endocrinology · 2023Article
- Metabolic syndrome as risk factor for left ventricular hypertrophy in children with chronic kidney disease.Frontiers in endocrinology · 2023Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
RATIONALE &
objectiveTraditional and nontraditional cardiovascular disease risk factors are highly prevalent in children with chronic kidney disease (CKD). We examined the longitudinal association of adiposity with cardiac damage among children with CKD and explored whether this association was modified by sex. STUDY
designProspective cohort study. SETTING &
participantsChildren with mild-to-moderate CKD enrolled in the Chronic Kidney Disease in Children (CKiD) Study at 49 pediatric nephrology centers across North America. EXPOSURE: Age- and sex-specific body mass index (BMI) z score. OUTCOME: Age- and sex-specific left ventricular mass index (LVMI) z score and left ventricular hypertrophy (LVH). ANALYTICAL APPROACH: Longitudinal analyses using mixed-effects models to estimate sex-specific associations of BMI z scores with LVMI z score and with LVH, accounting for repeated measurements over time.
resultsAmong 725 children with 2,829 person-years of follow-up, median age was 11.0 years and median estimated glomerular filtration rate was 52.6mL/min/1.73m LIMITATIONS: Not all children had repeated measurements. LVH is a surrogate and not a hard cardiac outcome. The observational design limits causal inference.
conclusionsIn children, adiposity is independently associated with the markers of cardiac damage, LVMI z score and LVH. This association is stronger among girls than boys. Pediatric overweight and obesity may therefore have a substantial impact on cardiovascular risk among children with CKD.
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