Evidence map›Paper›PMID 32389105›Full record

ArticleCritical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine2020

Study protocol and statistical analysis plan for the Liberal Glucose Control in Critically Ill Patients with Pre-existing Type 2 Diabetes (LUCID) trial.

Alexis P Poole, Mark E Finnis, James Anstey, Rinaldo Bellomo, Shailesh Bihari, Vishwanath Biradar, Sarah Doherty, Glenn Eastwood, Simon Finfer, Craig J French and 16 more

Open access · greenAbstract readClinical Trial Protocol
PubMed Full text at PMC
In one paragraph

Article in Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Critical care nutrition and the legacy of Rinaldo Bellomo.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Alexis P PooleDiscipline of Acute Care Medicine, University of Adelaide, Adelaide, SA, Australia. Alexis.Poole@adelaide.edu.au.
Mark E FinnisDiscipline of Acute Care Medicine, University of Adelaide, Adelaide, SA, Australia.
James AnsteyDepartment of Intensive Care, Royal Melbourne Hospital, Melbourne, VIC, Australia.
Rinaldo BellomoDepartment of Intensive Care, Austin Hospital, Melbourne, VIC, Australia.
Shailesh BihariDepartment of Intensive and Critical Care Unit, Flinders Medical Centre, Adelaide, SA, Australia.
Vishwanath BiradarDepartment of Intensive Care, Lyell McEwin Hospital, Adelaide, SA, Australia.
Sarah DohertyDepartment of Intensive Care, Royal Melbourne Hospital, Melbourne, VIC, Australia.
Glenn EastwoodDepartment of Intensive Care, Austin Hospital, Melbourne, VIC, Australia.
Simon FinferThe George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.
Craig J FrenchDepartment of Intensive Care, Western Health, Melbourne, VIC, Australia.
Angaj GhoshIntensive Care Unit, Northern Health, Melbourne, VIC, Australia.
Simon HellerClinical Diabetes, Endocrinology and Metabolism, University of Sheffield, Sheffield, United Kingdom.
Michael HorowitzEndocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.
Palash KarDiscipline of Acute Care Medicine, University of Adelaide, Adelaide, SA, Australia.
Peter S KrugerDepartment of Intensive Care, Princess Alexandra Hospital, Brisbane, QLD, Australia.
Matthew J MaidenDiscipline of Acute Care Medicine, University of Adelaide, Adelaide, SA, Australia.
Johan MårtenssonSection of Anaesthesia and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institutet, Solna, Sweden.
Colin J McArthurDepartment of Critical Care Medicine, Auckland District Health Board, Auckland, New Zealand.
Shay P McGuinnessCardiothoracic and Vascular Intensive Care and High Dependency Unit, Auckland District Health Board, Auckland, New Zealand.
Paul J SecombeDepartment of Intensive Care, Alice Springs Hospital, Alice Springs, NT, Australia.
Antony E TobinDepartment of Intensive Care, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia.
Andrew A UdyDepartment of Intensive Care, The Alfred Hospital, Melbourne, VIC, Australia.
Paul J YoungMedical Research Institute of New Zealand, Wellington, New Zealand.
Adam M DeaneDepartment of Intensive Care, Royal Melbourne Hospital, Melbourne, VIC, Australia. Adam.Deane@mh.org.au.
LUCID Study Investigators
ANZICS Clinical Trials Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundContemporary glucose management of intensive care unit (ICU) patients with type 2 diabetes is based on trial data derived predominantly from patients without type 2 diabetes. This is despite the recognition that patients with type 2 diabetes may be relatively more tolerant of hyperglycaemia and more susceptible to hypoglycaemia. It is uncertain whether glucose targets should be more liberal in patients with type 2 diabetes.

objectiveTo detail the protocol, analysis and reporting plans for a randomised clinical trial - the Liberal Glucose Control in Critically Ill Patients with Pre-existing Type 2 Diabetes (LUCID) trial - which will evaluate the risks and benefits of targeting a higher blood glucose range in patients with type 2 diabetes. DESIGN, SETTING, PARTICIPANTS AND

interventionA multicentre, parallel group, open label phase 2B randomised controlled clinical trial of 450 critically ill patients with type 2 diabetes. Patients will be randomised 1:1 to liberal blood glucose (target 10.0-14.0 mmol/L) or usual care (target 6.0-10.0 mmol/L).

main outcome measuresThe primary endpoint is incident hypoglycaemia (< 4.0 mmol/L) during the study intervention. Secondary endpoints include biochemical and feasibility outcomes. RESULTS AND

conclusionThe study protocol and statistical analysis plan described will delineate conduct and analysis of the trial, such that analytical and reporting bias are minimised.

trial registrationThis trial has been registered on the Australian New Zealand Clinical Trials Registry (ACTRN No. 12616001135404) and has been endorsed by the Australian and New Zealand Intensive Care Society Clinical Trials Group.

Indexed as

Blood GlucoseCritical CareDiabetes Mellitus, Type 2Randomized Controlled Trials as TopicAustraliaChronic DiseaseCritical IllnessHumansNew ZealandBlood Glucose

Identifiers

PMID32389105
PMCPMC10692470
OpenAlexW3023882597

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.