Evidence map›Paper›PMID 32388916›Full record

ArticlePediatric transplantation2020

Promoting medication adherence from the perspective of adolescent and young adult kidney transplant recipients, parents, and health care professionals: A TAKE-IT TOO study.

Christina Nguyen, Mary Amanda Dew, Taya Irizarry, Mary McNulty, Janet Rennick, Bärbel Knäuper, Annie Descoteaux, Audrey Grenier, Lovemine Jeannot, Bethany J Foster and 2 more

Open access · greenAbstract read
In one paragraph

Article in Pediatric transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Christina NguyenDivision of Pediatric Nephrology, UH Rainbow Babies and Children's Hospital Division of Pediatrics, Cleveland, OH, USA.
Mary Amanda DewPsychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Taya IrizarryAcute and Tertiary Care, University of Pittsburgh School of Nursing, Pittsburgh, PA, USA.
Mary McNultyPsychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Janet RennickResearch Institute of the McGill University Health Centre, Montreal, QC, Canada.
Bärbel KnäuperPsychology, McGill University, Montreal, QC, Canada.
Annie DescoteauxCentre Hospitalier Universitaire Ste. Justine, Montreal, QC, Canada.
Audrey GrenierMcGill University Health Centre, Montreal, QC, Canada.
Lovemine JeannotResearch Institute of the McGill University Health Centre, Montreal, QC, Canada.
Bethany J FosterResearch Institute of the McGill University Health Centre, Montreal, QC, Canada.
Annette J DeVito DabbsAcute and Tertiary Care, University of Pittsburgh School of Nursing, Pittsburgh, PA, USA.ORCID 0000-0003-3325-435X
all TAKE-IT TOO Investigators
McGill University Health Centre · CAUniversity of Pittsburgh · USCentre Hospitalier Universitaire Sainte-Justine · CAMcGill University · CARainbow Babies & Children's Hospital · US

Funding

TAKE-IT TOO: Teen Adherence in KidnEy transplant Improving Tracking To Optimize OutcomesR01DK110737 · NIDDK · MCGILL UNIVERSITY HEALTH CTR RES INST · PI DE VITO DABBS, ANNETTE J, FOSTER, BETHANY JOY · 2016 to 2020
$2.8M
NIDDK NIH HHS R01 DK110737NIH HHS R01DK15017
6 · The paper itself

Abstract

Medication non-adherence is an important factor limiting allograft survival after kidney transplantation in AYA. Some interventions, including the TAKE-IT, showed some success in promoting adherence but the potential for scalability and use in routine clinical practice is limited. We applied user-centered design to gather the perspectives of recipients, parents, and health professionals concerning their needs, challenges, and potential intervention strategies to design an optimal, multi-component medication adherence intervention. The qualitative study was conducted at four Canadian and three American kidney transplant programs. Separate focus groups for recipients, parents, and health professionals were convened to explore these stakeholders' perspectives. Directed content analysis was employed to identify themes that were shared vs distinct across stakeholders. All stakeholder groups reported challenges related to taking medications on time in the midst of their busy schedules and the demands of transitioning toward independence during adolescence. The stakeholders also made suggestions for the multi-component behavioral intervention, including an expanded electronic pillbox and companion website, education materials, and customized digitized features to support shared responsibility and communication among recipients, parents, and health professionals. Several suggestions regarding the functionality and features of the potential intervention reported in this early stage will be explored in more depth as the iterative process unfolds. Our approach to actively involve all stakeholders in the process increases the likelihood of designing an adherence intervention that is truly user-informed and fit for the clinical setting.

Indexed as

Kidney TransplantationStakeholder ParticipationAdolescentAdultAgedChildFemaleGraft RejectionHealth PersonnelHumansImmunosuppressive AgentsMaleMedication AdherenceMentoringMiddle AgedNeeds AssessmentImmunosuppressive Agentsadolescent and young adultkidney transplantationmedication adherencepediatric

Identifiers

PMID32388916
PMCPMC7392786
OpenAlexW3022074039

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.