ReviewArchives of toxicology2020
Arsenic intoxication: general aspects and chelating agents.
Review in Archives of toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 145 citations in OpenAlex.
- The Genetic Exploration of the Association Between Heavy Metal Exposure in Environmental Pollution and Multi-system Diseases.Biological trace element research · 2026Article
- Nutritional Intervention with Selenium-Rich Rice Mitigates Arsenic-Induced Liver and Kidney Toxicity in Mice.Biological trace element research · 2026Article
- Metallothioneins in Neurodegenerative Diseases: Metal Homeostasis, Autoimmunity, and Therapeutic Potential.Molecular neurobiology · 2026Review
- Rivers of Tears - Convergent, Multi-Scale Approaches to Monitor and Optimize the Health of Our World's Inhabitants.Global challenges (Hoboken, NJ) · 2026Article
- Cerebral Edema Secondary to Heavy Metal Toxicity From Siddha Medicine: A Case Report and Case-Based Review.Case reports in neurological medicine · 2026Article
- Geochemical tales of individual lives in the industrial revolution: Untangling the impact of pollutant exposure in two English towns.Science advances · 2025Article
- Molecular Mechanisms Behind Organ-Related Aging and Regulatory Effects of Natural Therapeutics.Cell biochemistry and biophysics · 2025Review
- Arsenome, Arsenobolome, and Arsenobiolome.International journal of molecular sciences · 2025Review
- Advancements in heavy metal detection using microneedle array technology.Toxicology mechanisms and methods · 2025Article
- Selenium Improves Arsenic-Induced Male Reproductive Dysfunction by Regulating H3K14ac Level.Biological trace element research · 2025Article
- A review on arsenic contamination in drinking water: sources, health impacts, and remediation approaches.RSC advances · 2025Review
- Effect of garcinol against arsenic-induced neurobehavioral alterations and liver and kidney dysfunction in albino mice.BioMedicine · 2025Article
- A review of acaricides and their resistance mechanisms in hard ticks and control alternatives with synergistic agents.Acta tropica · 2025Review
- Heavy Metal Contamination: Sources, Health Impacts, and Sustainable Mitigation Strategies with Insights from Nigerian Case Studies.F1000Research · 2025Review
- Effect of Gentianella acuta (Michx.) Hulten against the arsenic-induced development hindrance of mouse oocytes.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Article
- Unraveling the role of heavy metals xenobiotics in cancer: a critical review.Discover oncology · 2024Review
- Recent developments in speciation and determination of arsenic in marine organisms using different analytical techniques. A review.RSC advances · 2024Review
- Myricetin ameliorates arsenic-induced hematological changes, immune dysfunction, oxidative stress, hepatic and renal injuries and promotes inflammatory genes in rats.Open veterinary journal · 2024Article
- Copper, Iron, Cadmium, and Arsenic, All Generated in the Universe: Elucidating Their Environmental Impact Risk on Human Health Including Clinical Liver Injury.International journal of molecular sciences · 2024Review
- Betaine Protects Mice from Cardiotoxicity Triggered by Sodium Arsenite Through Antioxidative and Anti-inflammatory Pathways.Cardiovascular toxicology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arsenic (As) is widely used in the modern industry, especially in the production of pesticides, herbicides, wood preservatives, and semiconductors. The sources of As such as contaminated water, air, soil, but also food, can cause serious human diseases. The complex mechanism of As toxicity in the human body is associated with the generation of free radicals and the induction of oxidative damage in the cell. One effective strategy in reducing the toxic effects of As is the usage of chelating agents, which provide the formation of inert chelator-metal complexes with their further excretion from the body. This review discusses different aspects of the use of metal chelators, alone or in combination, in the treatment of As poisoning. Consideration is given to the therapeutic effect of thiol chelators such as meso-2,3-dimercaptosuccinic acid, sodium 2,3-dimercapto-1-propanesulfonate, 2,3-dimercaptopropanol, penicillamine, ethylenediaminetetraacetic acid, and other recent agents against As toxicity. The review also considers the possible role of flavonoids, trace elements, and herbal drugs as promising natural chelating and detoxifying agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.