ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2021
Feline sporotrichosis: a case series of itraconazole-resistant Sporothrix brasiliensis infection.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 76 citations in OpenAlex.
- Biogenic Silver Nanoparticle: In vitro antifungal activity against Sporothrix brasiliensis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Antifungal and Therapeutic Evaluation of l- and d‑Enantiomers of a Plant Defensin-Inspired Peptide againstACS omega · 2026Article
- Electroporation as an adjunctive therapy for refractory feline sporotrichosis: A two-case report.Medical mycology case reports · 2026Article
- In Vitro Antifungal Drug Susceptibility of Feline Sporothrix schenckii Complex Isolates, Thailand, 2023-2025.Emerging infectious diseases · 2026Article
- Establishment of epidemiological cutoff values for clinically relevantAntimicrobial agents and chemotherapy · 2026Article
- Chemical modifications of diphenyl diselenide enhance its anti-Sporothrix spp. activity and exhibit synergism with itraconazole.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Nanodrugs for Subcutaneous Mycoses: Applications, Antifungal Performance, and Translational Perspectives.Microorganisms · 2026Review
- Experience implementing a sporotrichosis surveillance and control program in free-roaming cats on a university campus.PloS one · 2026Article
- Emergence of difficult-to-treat lymphocutaneous sporotrichosis? Analysis based on three cases with high and low MIC Sporothrix brasiliensis isolates.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Article
- Article
- Ozonized sunflower oil as an integrative therapy for feline sporotrichosis: a randomized clinical trial.Open veterinary journal · 2025Article
- A Novel In Vitro Host-Pathogen Model for Felis catus and Sporothrix Zoonotic Species Investigation.Journal of basic microbiology · 2025Article
- Sporothrix brasiliensis Treatment Failure without Initial Elevated Itraconazole MICs in Felids at Border of Brazil.Emerging infectious diseases · 2025Article
- Prospective Uncontrolled Interventional Study of Itraconazole and β-Glucans (Veterinary sciences · 2025Article
- In Vitro Evidence for the Efficacy of Manuka Honey and Its Components Against the Major Human PathogenicPharmaceuticals (Basel, Switzerland) · 2025Article
- Therapeutic alternatives for sporotrichosis induced by wild-type and non-wild-type Sporothrix schenckii through in vitro and in vivo assessment of enilconazole, isavuconazole, posaconazole, and terbinafine.Scientific reports · 2025Article
- Sporotrichosis incidence and risk factors in cats in Thonburi District, Bangkok, Thailand: A retrospective study.Open veterinary journal · 2025Article
- Case report: Severe ulcerative dermatitis leading to sepsis in a cat with sporotrichosis byFrontiers in veterinary science · 2025Article
- Combination therapy of itraconazole and an acylhydrazone derivative (D13) for the treatment of sporotrichosis in cats.Microbiology spectrum · 2024Article
- In vitro activity of the anthelmintic drug niclosamide against Sporothrix spp. strains with distinct genetic and antifungal susceptibility backgrounds.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
The treatment of feline sporotrichosis is a challenge for veterinary clinicians since refractory cases may occur, due either to patient and/or to pharmacological management errors or due to the development of antifungal resistance. Thus, we aimed to describe the therapeutic history of feline cases infected by itraconazole-resistant Sporothrix brasiliensis in an endemic region of Southern Brazil. Medical records of cats attended at the Veterinary Clinic Hospital (Pelotas/RS, Brazil) between 2016 and 2017 were reviewed. Twelve cases of infection by S. brasiliensis with that showed high minimum inhibitory concentration (MIC) values (≥ 4 μg/mL) to itraconazole by M38-A2 of CLSI were selected. At the hospital consultation, disseminated (cats 1-l0, 12) and localized (cat 11) skin lesions remained in the cats, even after treatment with fluconazole, ketoconazole (02/12), and itraconazole (ITZ, 09/12) performed before this study. High doses (25-100 mg/kg/day) of ITZ for up to 4 months (03/12, cats 2, 6, 12) or over 12 months (05/12, cats 1, 5, 7, 8, 11) did not provide a clinical cure, except for the association of ITZ plus potassium iodide (01/12, cat 12) for 3 months, which proved useful in infections with itraconazole-resistant S. brasiliensis. However, the combined issues of abandonment of therapy by owners for financial reasons, difficulties surrounding therapy administration (03/12, cats 6, 11, 12), and the inappropriate choice of medication (01/12, cat 6), together reflect the reality of this endemic region, which greatly compromises clinical healing. This study highlighted the occurrence of refractory cases by itraconazole-resistant S. brasiliensis in cats from Southern Brazil, as well as the abandonment of treatment and therapeutic errors. We warn of the need for antifungal susceptibility tests to adapt therapeutic protocols in feline sporotrichosis.
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