Evidence map›Paper›PMID 32388741›Full record

Observational studyAnnals of surgical oncology2020

Treatment and Survival of Elderly Patients with Stage I-II Pancreatic Cancer: A Report of the EURECCA Pancreas Consortium.

Jesse V Groen, Tom A Douwes, Elizabeth van Eycken, Lydia G M van der Geest, Tom B Johannesen, Marc G Besselink, Bas Groot Koerkamp, Johanna W Wilmink, Bert A Bonsing, Johanna E A Portielje and 4 more

Open access · hybridAbstract readObservational Study
In one paragraph

Observational study in Annals of surgical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Pancreatic cancer.Nature reviews. Disease primers · 2026
    Review
  2. Article
  3. Review
  4. Update on the management of older patients with pancreatic adenocarcinoma: a perspective from medical oncology.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Jesse V GroenDepartment of Surgery, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. J.V.Groen@lumc.nl.ORCID http://orcid.org/0000-0002-2438-4665
Tom A DouwesDepartment of Surgery, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.
Elizabeth van EyckenBelgian Cancer Registry, Brussels, Belgium.
Lydia G M van der GeestDepartment of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands.
Tom B JohannesenRegistry Department, The Cancer Registry of Norway, Oslo, Norway.
Marc G BesselinkDepartment of Surgery, Cancer Center Amsterdam Amsterdam, UMC, University of Amsterdam, Amsterdam, The Netherlands.
Bas Groot KoerkampDepartment of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands.
Johanna W WilminkDepartment of Medical Oncology, Cancer Center Amsterdam, UMC, University of Amsterdam, Amsterdam, The Netherlands.
Bert A BonsingDepartment of Surgery, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.
Johanna E A PortieljeDepartment of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
Cornelus J H van de VeldeDepartment of Surgery, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.
Esther BastiaannetDepartment of Surgery, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.
J Sven D MieogDepartment of Surgery, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.
Dutch Pancreatic Cancer Group
Leiden University Medical Center · NLCancer Registry of Norway · NOErasmus MC · NLNetherlands Comprehensive Cancer Organisation · NL

Funding

Bas Mulder Award from the Alpe d'HuZes foundation/Dutch Cancer Society UL2015-7665
6 · The paper itself

Abstract

backgroundElderly patients with pancreatic cancer are underrepresented in clinical trials, resulting in a lack of evidence.

objectiveThe aim of this study was to compare treatment and overall survival (OS) of patients aged ≥ 70 years with stage I-II pancreatic cancer in the EURECCA Pancreas Consortium.

methodsThis was an observational cohort study of the Belgian (BE), Dutch (NL), and Norwegian (NOR) cancer registries. The primary outcome was OS, while secondary outcomes were resection, 90-day mortality after resection, and (neo)adjuvant and palliative chemotherapy.

resultsIn total, 3624 patients were included. Resection (BE: 50.2%; NL: 36.2%; NOR: 41.3%; p < 0.001), use of (neo)adjuvant chemotherapy (BE: 55.9%; NL: 41.9%; NOR: 13.8%; p < 0.001), palliative chemotherapy (BE: 39.5%; NL: 6.0%; NOR: 15.7%; p < 0.001), and 90-day mortality differed (BE: 11.7%; NL: 8.0%; NOR: 5.2%; p < 0.001). Furthermore, median OS in patients with (BE: 17.4; NL: 15.9; NOR: 25.4 months; p < 0.001) and without resection (BE: 7.0; NL: 3.9; NOR: 6.5 months; p < 0.001) also differed.

conclusionsDifferences were observed in treatment and OS in patients aged ≥ 70 years with stage I-II pancreatic cancer, between the population-based cancer registries. Future studies should focus on selection criteria for (non)surgical treatment in older patients so that clinicians can tailor treatment.

Indexed as

Pancreatic NeoplasmsAgedChemotherapy, AdjuvantCohort StudiesFemaleHumansMalePancreasPancreatectomy

Identifiers

PMID32388741
PMCPMC7669775
OpenAlexW3022936562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.