ArticleEuropean journal of nutrition2021
Association of magnesium intake and vitamin D status with cognitive function in older adults: an analysis of US National Health and Nutrition Examination Survey (NHANES) 2011 to 2014.
Article in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Magnesium and Cognitive Health in Adults: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2024Pooled it
- Frailty and incident cognitive impairment in patients with CKD: sex-frailty paradox in the Chronic Renal Insufficiency Cohort (CRIC).GeroScience · 2026Article
- Serum Creatinine Clearance and Cognitive Function in Older Adults: Mediating Effects of Systemic Inflammatory Response Index.Brain and behavior · 2026Article
- Serum Albumin/Globulin Ratio and Cognitive Function in Americans: A Linear Association.Brain and behavior · 2025Article
- Exploring the potential relationship between kidney disease index and cognitive dysfunction: a machine learning approach with NHANES data.BMC geriatrics · 2025Article
- Assessing the Impact of Estimated Glucose Disposal Rate (eGDR) on Cognitive Function in Older Adults: A NHANES-Based Machine Learning Study.CNS neuroscience & therapeutics · 2025Article
- Exploring the association between hemoglobin glycation index and cognitive function in older adults with hypertension: a cross-sectional study.BMC geriatrics · 2025Article
- Combined impact of neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and cognitive function on all-cause mortality in older adults: a population-based study.Lipids in health and disease · 2025Article
- Association of multiple dietary metal intake with cardiovascular-kidney-metabolic syndrome: a cross-sectional study based on NHANES 2003-2018.Frontiers in nutrition · 2025Article
- Cross-sectional and longitudinal associations of magnesium intake and cognition in the Healthy Aging Longitudinal Study in Taiwan.European journal of nutrition · 2024Article
- Article
- Association between fibrosis-4 index and cognitive impairment in elderly patients with hypertension: A cross-sectional study.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- The Concurrent Association of Magnesium and Calcium Deficiencies with Cognitive Function in Older Hospitalized Adults.Nutrients · 2024Article
- Multi-element Exposure and Cognitive Function in Rural Elderly Chinese.Biological trace element research · 2024Article
- Neuroprotective effects of magnesium: implications for neuroinflammation and cognitive decline.Frontiers in endocrinology · 2024Review
- Association between weight-adjusted-waist index and cognitive decline in US elderly participants.Frontiers in nutrition · 2024Article
- The impact of vitamin E, vitamin B6, and niacin intake on cataract incidence based on NHANES 2005-2008 data.Frontiers in nutrition · 2024Article
- The role of composite dietary antioxidants in elderly cognitive function: insights from NHANES.Frontiers in nutrition · 2024Article
- Higher intake of certain nutrients among older adults is associated with better cognitive function: an analysis of NHANES 2011-2014.BMC nutrition · 2023Article
- Association Between Serum Neurofilament Light Chain and Cognitive Performance Among Older Adults in the United States: A Cross-Sectional Study.Neurology and therapy · 2023Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
purposeReduced cognitive function associated with aging has gained increasing attention as the US population ages. Magnesium plays a critical role in vitamin D biosynthesis and metabolism; and deficiencies in magnesium and vitamin D show associations with poor cognition. However, no study has examined their interaction. This study aimed to evaluate the associations of magnesium intake and serum 25-hydroxyvitamin D (25(OH)D) concentrations, indicating vitamin D status, with cognition, and interaction between these nutrients in older adults.
methodsBased on the National Health and Nutrition Survey (NHANES) 2011-2014, the study included 2466 participants aged ≥ 60 years who completed the Digit Symbol Substitution Test (DSST) and had data available on serum 25(OH)D and magnesium intake. Cognitive impairment was defined as a DSST score lower than the lowest quartile. Serum 25(OH)D concentrations were measured by HPLC-tandem mass spectrometry.
resultsHigher total magnesium intake was independently associated with higher DSST scores (highest quartile vs lowest: β = 4.34, 95% CI 1.14-7.54). The association of total magnesium intake with high DSST score was primarily observed among women, non-Hispanic whites, physically active participants and those with sufficient vitamin D status, although the interactions were not significant. The odds of cognitive impairment was reduced with increasing intake of total magnesium (p trend < 0.01) and higher level of serum 25(OH)D (p trend = 0.05).
conclusionsFindings suggest that high magnesium intake alone may improve cognitive function in older adults, and the association may be stronger among subjects with sufficient vitamin D status. Further studies are needed to confirm these findings.
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