ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2020
Multi-Stage Group Testing Improves Efficiency of Large-Scale COVID-19 Screening.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Pooled it
- Performance Evaluation of Nasopharyngeal Swab Pooling to Improve SARS-CoV-2 Testing Capacity via Closed Real-Time RT‒PCR Assays.Infection and drug resistance · 2026Article
- A proactive/reactive mass screening approach with uncertain symptomatic cases.PLoS computational biology · 2024Article
- Semi-quantitative group testing for efficient and accurate qPCR screening of pathogens with a wide range of loads.BMC bioinformatics · 2024Article
- Clinical performance of AI-integrated risk assessment pooling reveals cost savings even at high prevalence of COVID-19.Scientific reports · 2024Article
- An Open One-Step RT-qPCR for SARS-CoV-2 detection.PloS one · 2024Article
- COVID-19 health policy evaluation: integrating health and economic perspectives with a data envelopment analysis approach.The European journal of health economics : HEPAC : health economics in prevention and care · 2022Article
- Using trajectory modeling of spatio-temporal trends to illustrate disparities in COVID-19 death in flint and Genesee County, Michigan.Spatial and spatio-temporal epidemiology · 2022Article
- Singleplex, multiplex and pooled sample real-time RT-PCR assays for detection of SARS-CoV-2 in an occupational medicine setting.Scientific reports · 2022Article
- Use of compressed sensing to expedite high-throughput diagnostic testing for COVID-19 and beyond.PLoS computational biology · 2022Article
- Clinical and epidemiological aspects of SARS-CoV-2 infection among pregnant and postpartum women in Mozambique: a prospective cohort study.Reproductive health · 2022Article
- Simulation of group testing scenarios can boost COVID-19 screening power.Scientific reports · 2022Article
- Boosting SARS-CoV-2 detection combining pooling and multiplex strategies.Scientific reports · 2022Article
- Smart pooling: AI-powered COVID-19 informative group testing.Scientific reports · 2022Article
- Pooled testing of traced contacts under superspreading dynamics.PLoS computational biology · 2022Article
- Optimal multi-stage group partition for efficient coronavirus screening.Annals of operations research · 2022Article
- Screening multi-dimensional heterogeneous populations for infectious diseases under scarce testing resources, with application to COVID-19.Naval research logistics · 2022Article
- Efficient COVID-19 testing via contextual model based compressive sensing.Pattern recognition · 2022Article
- Article
- DOPE: D-Optimal Pooling Experimental design with application for SARS-CoV-2 screening.Journal of the American Medical Informatics Association : JAMIA · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSARS-CoV-2 test kits are in critical shortage in many countries. This limits large-scale population testing and hinders the effort to identify and isolate infected individuals.
objectiveHerein, we developed and evaluated multi-stage group testing schemes that test samples in groups of various pool sizes in multiple stages. Through this approach, groups of negative samples can be eliminated with a single test, avoiding the need for individual testing and achieving considerable savings of resources. STUDY
designWe designed and parameterized various multi-stage testing schemes and compared their efficiency at different prevalence rates using computer simulations.
resultsWe found that three-stage testing schemes with pool sizes of maximum 16 samples can test up to three and seven times as many individuals with the same number of test kits for prevalence rates of around 5% and 1%, respectively. We propose an adaptive approach, where the optimal testing scheme is selected based on the expected prevalence rate.
conclusionThese group testing schemes could lead to a major reduction in the number of testing kits required and help improve large-scale population testing in general and in the context of the current COVID-19 pandemic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.