ArticleNeuroImage. Clinical2020
Greater Individual Variability in Functional Brain Activity during Working Memory Performance in young people with Autism and Executive Function Impairment.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07699159 (Cohort Network for Adolescents and Youth With multipLe Mental Health Conditions), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cohort Network for Adolescents and Youth With multipLe Mental Health Conditions (CALM): A Master Observational Trial
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neural dysfunctions associated with atypical memory in ASD: an ALE meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Brain correlates of declarative memory atypicalities in autism: a systematic review of functional neuroimaging findings.Molecular autism · 2023Pooled it
- Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment Reduces Variability in Brain Function in Schizophrenia: Data From a Double-Blind, Randomized, Sham-Controlled Trial.Schizophrenia bulletin · 2025Trial
- Transdiagnostic Neurobiology of Social Cognition and Individual Variability as Measured by Fractional Amplitude of Low-Frequency Fluctuation in Autism and Schizophrenia Spectrum Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Cognitive-Behavioral Predictors of Individual Variability of Functional Connectivity in Healthy Young Adults.Research square · 2026Article
- Brain idiosyncrasy during biological-motion perception is amplified in autistic individuals with intellectual impairment.Journal of neurodevelopmental disorders · 2026Article
- Differential connectivity between core hubs underlying demanding executive functions in schizophrenia compared to autism and control adults.Frontiers in psychiatry · 2026Article
- Lower Cortical Activation and Altered Functional Connectivity Characterize Passive Auditory Spatial Attention in ASD.Autism research : official journal of the International Society for Autism Research · 2025Article
- Lateral Cerebellar Theta Burst Stimulation Can Modulate Default Mode Network Connectivity in Autistic Adults.Cerebellum (London, England) · 2025Article
- Lower cortical activation and altered functional connectivity characterize passive auditory spatial attention in ASD.bioRxiv : the preprint server for biology · 2025Article
- Developmental changes of visuospatial working memory in autistic children and adolescents.Psychological medicine · 2025Article
- Task-based functional neural correlates of social cognition across autism and schizophrenia spectrum disorders.Molecular autism · 2024Article
- Heterogeneity in functional connectivity: Dimensional predictors of individual variability during rest and task fMRI in psychosis.Progress in neuro-psychopharmacology & biological psychiatry · 2024Article
- Higher general intelligence is associated with stable, efficient, and typical dynamic functional brain connectivity patterns.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- High performers demonstrate greater neural synchrony than low performers across behavioral domains.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Association of Sex With Neurobehavioral Markers of Executive Function in 2-Year-Olds at High and Low Likelihood of Autism.JAMA network open · 2023Article
- Increased Intra-Subject Variability of Neural Activity During Speech Production in People with Autism Spectrum Disorder.Research in autism spectrum disorders · 2022Article
- Longer illness duration is associated with greater individual variability in functional brain activity in Schizophrenia, but not bipolar disorder.NeuroImage. Clinical · 2022Article
- Looking Back at the Next 40 Years of ASD Neuroscience Research.Journal of autism and developmental disorders · 2021Review
- Chronic Fatigue in Cancer, Brain Connectivity and Reluctance to Engage in Physical Activity: A Mini-Review.Frontiers in oncology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundIndividuals with autism spectrum disorder (ASD) often present with executive functioning (EF) deficits, including spatial working memory (SWM) impairment, which impedes real-world functioning. The present study examined task-related brain activity, connectivity and individual variability in fMRI-measured neural response during an SWM task in older youth and young adults with autism and clinically significant EF impairment.
methodsNeuroimaging was analyzed in 29 individuals with ASD without intellectual disability who had clinically significant EF impairment on the Behavior Rating Inventory of Executive Function, and 20 typically developing controls (participant age range=16-34). An SWM N-Back task was performed during fMRI. SWM activity (2-Back vs. 0-Back) and task-related dorsolateral prefrontal cortex (DLPFC) connectivity was examined within and between groups. Variability of neural response during SWM was also examined.
resultsDuring SWM performance both groups activated the expected networks, and no group differences in network activation or task-related DLPFC-connectivity were found. However, greater individual variability in the pattern of SWM activity was found in the ASD versus the typically developing control group.
conclusionsWhile there were no group differences in SWM task-evoked activity or connectivity, fronto-parietal network engagement was found to be more variable/idiosyncratic in ASD. Our results suggest that the fronto-parietal network may be shifted or sub-optimally engaged during SWM performance in participants with ASD with clinically significant EF impairment, with implications for developing targeted interventions for this subgroup.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.