ArticleJournal of hepatology2020
Changing epidemiology and outcomes of acute kidney injury in hospitalized patients with cirrhosis - a US population-based study.
Article in Journal of hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Mortality of Acute Kidney Injury in Cirrhosis: A Systematic Review and Meta-Analysis of Over 5 Million Patients Across Different Clinical Settings.Alimentary pharmacology & therapeutics · 2025Pooled it
- The efficacy of novel biomarkers for the early detection and management of acute kidney injury: A systematic review.PloS one · 2025Pooled it
- Impact of acute kidney injury on the risk of mortality in patients with cirrhosis: a systematic review and meta-analysis.Renal failure · 2022Pooled it
- Non-linear association between AKI alert detection rate by physicians and medical costs.PloS one · 2025Trial
- Incidence, associated factors and prognostic association of acute kidney injury after TIPS: a multicenter retrospective study.Renal failure · 2026Article
- Integrated biomarkers and renal Doppler for early acute kidney injury diagnosis in hepatitis C virus cirrhosis.World journal of nephrology · 2026Article
- Evaluation of Kidney Function in Cirrhosis: Methods and Pitfalls.Diagnostics (Basel, Switzerland) · 2026Review
- Impact of cirrhosis on patients admitted with an exacerbation of acute chronic obstructive pulmonary disease: a nationwide analysis.Proceedings (Baylor University. Medical Center) · 2026Article
- Prognosis of critically ill patients with cirrhosis and acute kidney injury initiated on dialysis.BMC nephrology · 2026Article
- Clinical prediction of the mortality for acute kidney injury in decompensated cirrhosis.Scientific reports · 2026Article
- The global epidemiology of acute kidney injury: challenges and opportunities.Nature reviews. Nephrology · 2026Review
- Article
- Association between the C-reactive protein-triglyceride-glucose index (CTI) and the risk of acute kidney injury in critically ill patients with cirrhosis.BMC nephrology · 2025Article
- Factors and outcomes associated with acute kidney injury in brain tumor resection patients: insights from a large US database (2010-2019).Renal failure · 2025Article
- Ambulatory Acute Kidney Injury in Patients With Cirrhosis Is Common and Burdensome.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025Article
- Acute kidney injury stage 1a increases mortality of patients with cirrhosis: a prospective multicenter cohort study.Hepatology international · 2025Article
- A novel risk-predicted nomogram for acute kidney injury progression in decompensated cirrhosis: a double-center study in Vietnam.International urology and nephrology · 2025Article
- Clinical decision instruments for predicting mortality in patients with cirrhosis seeking emergency department care.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2025Article
- Acute kidney injury is associated with liver-related outcomes in patients with hepatitis B virus infection: a retrospective cohort study.BMC nephrology · 2025Article
- Efficacy of Contezolid in the Treatment of Catheter-Related Bloodstream Infections Caused by Methicillin-ResistantInfection and drug resistance · 2025Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
BACKGROUND &
aimsAcute kidney injury (AKI) is a significant clinical event in cirrhosis yet contemporary population-based studies on the impact of AKI on hospitalized cirrhotics are lacking. We aimed to characterize longitudinal trends in incidence, healthcare burden and outcomes of hospitalized cirrhotics with and without AKI using a nationally representative dataset.
methodsUsing the 2004-2016 National Inpatient Sample (NIS), admissions for cirrhosis with and without AKI were identified using ICD-9 and ICD-10 codes. Regression analysis was used to analyze the trends in hospitalizations, costs, length of stay and inpatient mortality. Descriptive statistics, simple and multivariable logistic regression were used to assess associations between individual characteristics, comorbidities, and cirrhosis complications with AKI and death.
resultsIn over 3.6 million admissions for cirrhosis, 22% had AKI. AKI admissions were more costly (median $13,127 [IQR $7,367-$24,891] vs. $8,079 [IQR $4,956-$13,693]) and longer (median 6 [IQR 3-11] days vs. 4 [IQR 2-7] days). Over time, AKI prevalence doubled from 15% in 2004 to 30% in 2016. CKD was independently and strongly associated with AKI (adjusted odds ratio 3.75; 95% CI 3.72-3.77). Importantly, AKI admissions were 3.75 times more likely to result in death (adjusted odds ratio 3.75; 95% CI 3.71-3.79) and presence of AKI increased risk of mortality in key subgroups of cirrhosis, such as those with infections and portal hypertension-related complications.
conclusionsThe prevalence of AKI is significantly increased among hospitalized cirrhotics. AKI substantially increases the healthcare burden associated with cirrhosis. Despite advances in cirrhosis care, a significant gap remains in outcomes between cirrhotics with and without AKI, suggesting that AKI continues to represent a major clinical challenge. LAY SUMMARY: Sudden damage to the kidneys is becoming more common in people who are hospitalized and have cirrhosis. Despite advances in cirrhosis care, those with damage to the kidneys remain at higher risk of dying.
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