Evidence map›Paper›PMID 32387575›Full record

ArticleJournal of pain and symptom management2020

Availability of Internationally Controlled Essential Medicines in the COVID-19 Pandemic.

Katherine Pettus, James F Cleary, Liliana de Lima, Ebtesam Ahmed, Lukas Radbruch

Open access · hybridAbstract read
In one paragraph

Article in Journal of pain and symptom management, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Pandemic treaty should include provisions for palliative care.Bulletin of the World Health Organization · 2023
    Article
  5. Article
  6. Analgosedation in Critically Ill Adults Receiving Extracorporeal Membrane Oxygenation Support.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2022
    Review
  7. Can You Hear Us Now? Equity in Global Advocacy for Palliative Care.Journal of pain and symptom management · 2022
    Article
  8. Review
  9. Pharmacists and opioid use disorder care during COVID-19: Call for action.Journal of the American College of Clinical Pharmacy : JACCP · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Observational
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Katherine PettusInternational Association for Hospice and Palliative Care, Houston, Texas, USA. Electronic address: Kpettus@iahpc.com.
James F ClearyWalther Center for Global Palliative Care, Indiana University, Indianapolis, Indiana, USA.
Liliana de LimaInternational Association for Hospice and Palliative Care, Houston, Texas, USA.
Ebtesam AhmedSt. John's University, New York, New York, USA.
Lukas RadbruchUniversity Hospital, Bonn, Germany.
American Academy of Hospice and Palliative Medicine · USIndiana University – Purdue University Indianapolis · USSt. John's University · USUniversity Hospital Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Section 2 of the 2019 World Health Organization Model List of Essential Medicines includes opioid analgesics formulations commonly used for the control of pain and respiratory distress, as well as sedative and anxiolytic substances such as midazolam and diazepam. These medicines, essential to palliative care, are regulated under the international drug control conventions overseen by United Nations specialized agencies and treaty bodies and under national drug control laws. Those national laws and regulations directly affect bedside availability of Internationally Controlled Essential Medicines (ICEMs). The complex interaction between national regulatory systems and global supply chains (now impacted by COVID-19 pandemic) directly affects bedside availability of ICEMs and patient care. Despite decades of global civil society advocacy in the United Nations system, ICEMs have remained chronically unavailable, inaccessible, and unaffordable in low- and-middle-income countries, and there are recent reports of shortages in high-income countries as well. The most prevalent symptoms in COVID-19 are breathlessness, cough, drowsiness, anxiety, agitation, and delirium. Frequently used medicines include opioids such as morphine or fentanyl and midazolam, all of them listed as ICEMs. This paper describes the issues related to the lack of availability and limited access to ICEMs during the COVID-19 pandemic in both intensive and palliative care patients in countries of all income levels and makes recommendations for improving access.

Indexed as

Coronavirus InfectionsHealth Services AccessibilityPandemicsPneumonia, ViralAnalgesicsCOVID-19Critical CareHumansInternationalityLegislation, DrugPalliative CareUnited NationsAnalgesicsbreathlessnessCOVID-19Essential medicinesmorphinepalliative care

Identifiers

PMID32387575
PMCPMC7204700
OpenAlexW3023471307

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.