SynthesisNeurotoxicology and teratology
Blood lead levels ≤10 micrograms/deciliter and executive functioning across childhood development: A systematic review.
Synthesis in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- Metals in tap water across child care and home environments: association between lead and early childhood executive function.Journal of exposure science & environmental epidemiology · 2026Article
- Associations between prenatal exposure to a mixture of lead, mercury and polychlorinated biphenyls and executive function in Inuit adolescents.Environmental research · 2025Article
- Childhood Pb-induced cognitive dysfunction: structural equation modeling of hot and cold executive functions.Journal of exposure science & environmental epidemiology · 2025Article
- Impact of early adolescent lead exposure on brain function and response: Findings from a Chinese cohort.Neurotoxicology · 2025Article
- The relationship between lead levels and reading acquisition in Spanish speakers, evidence from Uruguayan schoolers.Neurotoxicology · 2024Article
- Childhood lead exposure and sleep problems in adolescents: a longitudinal cohort study.International archives of occupational and environmental health · 2024Article
- Identification of high lead exposure locations in Ohio at the census tract scale using a generalizable geospatial hotspot approach.Journal of exposure science & environmental epidemiology · 2024Article
- Prenatal and childhood lead exposure is prospectively associated with biological markers of aging in adolescence.The Science of the total environment · 2024Article
- Assessing lead exposure in U.S. pregnant women using biological and residential measurements.The Science of the total environment · 2023Article
- Low level lead exposure in early childhood and parental education on adolescent IQ and working memory: a cohort study.Journal of exposure science & environmental epidemiology · 2023Article
- Childhood lead exposure and sex-based neurobehavioral functioning in adolescence.Neurotoxicology · 2022Article
- Early childhood lead exposure and adolescent heart rate variability: A longitudinal cohort study.Environmental research · 2022Article
- Rural and Urban Ecologies of Early Childhood Toxic Lead Exposure: The State of Kansas, 2005 to 2012.Kansas journal of medicine · 2022Article
- Blood lead and mercury levels are associated with low resting heart rate in community adolescent boys.International journal of hygiene and environmental health · 2021Article
- (Ascorb)ing Pb Neurotoxicity in the Developing Brain.Antioxidants (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
At low levels, the effects of lead on specific neurocognitive processes, such as executive functioning, is not well understood. The aim of this systematic review is to synthesize the empirical literature examining the relationship between prenatal and postnatal low blood lead levels and executive function across childhood development. This review considers the unity and diversity model of executive functioning by assessing the domains of working memory, cognitive flexibility, inhibition, attention, and unitary executive function separately. Nineteen studies met the inclusion criteria and were synthesized in the review. The results suggest an inverse association between postnatal lead exposure and executive function processes across childhood. The inverse relationship between postnatal lead exposure and working memory and cognitive flexibility in middle childhood is most strongly represented. Additionally, a marginal inverse relationship between postnatal lead exposure and unitary executive functioning and attention in middle childhood is suggested. The evidence does not support a relationship between postnatal lead and inhibition in middle childhood. Although there is support for the inverse relationship between low level lead exposure and executive function, lack of repeated exposure and outcome measures limit firm conclusions. Furthermore, the long-term impact of lead exposure on executive function outcomes is relatively unknown given lack of studies on adolescent populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.