Evidence map›Paper›PMID 32387526›Full record

ArticleMolecular and cellular endocrinology2020

Impaired oocyte maturation and ovulation in membrane progestin receptor (mPR) knockouts in zebrafish.

Xin-Jun Wu, Dong-Teng Liu, Shixi Chen, Wanshu Hong, Yong Zhu

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

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  10. Regulation of oocyte maturation: Role of conserved ERK signaling.Molecular reproduction and development · 2022
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Xin-Jun WuDepartment of Biology, East Carolina University, Greenville, NC, USA.
Dong-Teng LiuDepartment of Biology, East Carolina University, Greenville, NC, USA; College of Ocean and Earth Sciences, Xiamen University, Fujian, 361005, PR China.
Shixi ChenCollege of Ocean and Earth Sciences, Xiamen University, Fujian, 361005, PR China.
Wanshu HongCollege of Ocean and Earth Sciences, Xiamen University, Fujian, 361005, PR China.
Yong ZhuDepartment of Biology, East Carolina University, Greenville, NC, USA; College of Ocean and Earth Sciences, Xiamen University, Fujian, 361005, PR China. Electronic address: zhuy@ecu.edu.
Xiamen University · CNEast Carolina University · US

Funding

To characterize nongenomic progestin receptors via knockouts in zebrafishR15GM100461 · NIGMS · EAST CAROLINA UNIVERSITY · PI ZHU, YONG · 2013 to 2017
$757k
NIGMS NIH HHS R15 GM100461
6 · The paper itself

Abstract

Accumulating evidence suggest that membrane progestin receptor α (mPRα) is the membrane receptor mediating nongenomic progestin signaling that induces oocyte maturation in teleost. However, the involvement of other members of mPR family in oocyte maturation is still unclear. In this study, we found impaired oocyte maturation in zebrafish lacking mPRα1, mPRα2, mPRβ, or mPRγ2. In contrast, no difference was observed in oocyte maturation in the single knockout of mPRγ1, mPRδ, or mPRε. To study possible redundant functions of different mPRs in oocyte maturation, we generated a zebrafish line lacking all seven kinds of mPRs (mprs

Indexed as

Cell DifferentiationGene Knockout TechniquesOvulationAnimalsCell NucleusFemaleFertilityMutationOocytesOogenesisProgestinsZebrafishZebrafish ProteinsZygoteProgestinsZebrafish ProteinsmPROocyte maturationOogenesisOvulationPgrSubfertility

Identifiers

PMID32387526
PMCPMC7305657
OpenAlexW3023856925

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.