ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2020
Dose-volume correlates of the prevalence of patient-reported trismus in long-term survivorship after oropharyngeal IMRT: A cross-sectional dosimetric analysis.
Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 25 citations in OpenAlex.
- Imaging findings in the temporomandibular joint complex following radiation therapy for head and neck cancer: a review.Insights into imaging · 2026Review
- Heat Shock Protein 27 in Radiation-Induced Trismus: Mechanistic Insights and a Hypothesis-Generating Framework.Biomedicines · 2026Review
- Evaluation of Treatment Modalities for Radiation Therapy-Induced Trismus, Considering the Timing and Adherence to Progress in Mouth Opening and Oral Health-Related Quality of Life: A Systematic Review.Patient preference and adherence · 2026Review
- A higher number of chemotherapy cycles given during and after radiation is linked to increased rates of radiation-induced trismus in locally advanced nasopharyngeal cancer patients.Discover oncology · 2025Article
- Dental plaque-inspired peptide engineered to control plaque accumulation.Materials today. Bio · 2025Article
- Comment on: Intensity Modulated Radiotherapy in Head and Neck Cancer: Initial Experience of the First Treated Cases from North-East India.Indian journal of surgical oncology · 2023Article
- Article
- Assessment of mouth opening before and after head and neck radiotherapy in patients with intraoral stents.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2023Article
- De-escalated radiation for human papillomavirus virus-related oropharyngeal cancer: evolving paradigms and future strategies.Frontiers in oncology · 2023Review
- Deep Learning-Based Dose Prediction for Automated, Individualized Quality Assurance of Head and Neck Radiation Therapy Plans.Practical radiation oncologyArticle
- VMAT with CCC Algorithm Optimizes Trismus Prevention: Dose-Response Analysis of Jaw Muscles Dmean and Dmax in T3-T4 Nasopharyngeal Carcinoma.Technology in cancer research & treatmentArticle
- In Regard to Faravel et al. 2022: "Trismus Occurrence and Link With Radiotherapy Doses in Head and Neck Cancer Patients Treated With Chemoradiotherapy".Integrative cancer therapiesArticle
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1 author at 2 institutions in 3 countries.
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Abstract
purposeTo ascertain the dose-toxicity relationship for the prevalence of self-reported trismus in long-term survivors after intensity-modulated radiotherapy (IMRT) for oropharyngeal carcinoma (OPC). MATERIALS AND
methodsSelf-reported mouth opening was ascertained prospectively via a cross-sectional survey of OPC survivors using the intraoral finger-test. RT dose-volume histograms (DVHs) were generated for the following masticatory regions of interest: medial pterygoid, lateral pterygoid, and masseter muscles which were designated as ipsilateral or contralateral to the primary tumor. Trismus was defined as self-reported mouth opening of <3 finger-widths. Recursive partitioning analysis (RPA) was performed to identify the dose-volume thresholds associated with late trismus.
resultsAt a median follow-up time of 72 months (95% CI 68-74), 168 of the 587 (29%) survey respondents reported late trismus. Multivariate analysis demonstrated a significant association between late trismus and the following clinical variables: tonsillar primary site, advanced T stage, or higher total RT dose. RPA showed DVH-derived ipsilateral lateral pterygoid (ILP) mean dose of 61 Gy and volume receiving 27 Gy of at least 98.6% were independently associated with late trismus. The association between the ILP dosimetric parameters and the prevalence of late trismus was maintained after adjustment for clinical variables.
conclusionThe integral dose of IMRT results in unavoidable low/intermediate dose to non-target masticatory muscles that is associated with increased prevalence of late trismus in OPC survivors. Whenever clinically and technically applicable, applying the proposed dosimetric constraints to the ILP (V27 <98.6 and D
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