Evidence map›Paper›PMID 32387246›Full record

ReviewHeart rhythm2020

Recognizing COVID-19-related myocarditis: The possible pathophysiology and proposed guideline for diagnosis and management.

Bhurint Siripanthong, Saman Nazarian, Daniele Muser, Rajat Deo, Pasquale Santangeli, Mohammed Y Khanji, Leslie T Cooper, C Anwar A Chahal

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Heart rhythm, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04871867 (Assessement of Cardiac and Lung Consequences of COVID-19 Infection in the Professional Soccer Players), which is not on this map. Cited by 429 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
429citing papers in PubMed, 8 pooled it
101.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04871867 completednot on this map

Assessement of Cardiac and Lung Consequences of COVID-19 Infection in the Professional Soccer Players: A Prospective Observational Study

Typeobservational_patient_registrySponsorAmerican Hospital of ParisRan2020 to 2022Enrolled60ConditionsCovid19
3 · Its place in the literature

Who cites it

429 citing papers in PubMed, 8 syntheses or guidelines pooled it, 787 citations in OpenAlex.

  1. Pooled it
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  5. Brazilian Society of Cardiology Guideline on Myocarditis - 2022.Arquivos brasileiros de cardiologia · 2022
    Guideline
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
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  16. "Bridging the clinical, molecular and genetic perspectives on myocarditis in post-COVID-19 era".International journal of cardiology. Cardiovascular risk and prevention · 2026
    Review
  17. Five-year cardiovascular outcomes following COVID-19-associated carditis.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  18. Review
  19. Article
  20. Review

369 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Bhurint SiripanthongSchool of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.
Saman NazarianDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Daniele MuserDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Rajat DeoDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Pasquale SantangeliDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Mohammed Y KhanjiDepartment of Cardiology, Newham University Hospital and Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom; NIHR Barts Biomedical Research Centre, William Harvey Research Institute, Queen Mary University of London, London UK.
Leslie T CooperMayo Clinic, Jacksonville, Florida.
C Anwar A ChahalDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; Mayo Clinic, Rochester, Minnesota; Royal Papworth Hospital, Cambridge, United Kingdom. Electronic address: anwar.chahal@uphs.upenn.edu.
Hospital of the University of Pennsylvania · USBarts Health NHS Trust · GBMayo Clinic · USMayo Clinic in Florida · USUniversity of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human coronavirus-associated myocarditis is known, and a number of coronavirus disease 19 (COVID-19)-related myocarditis cases have been reported. The pathophysiology of COVID-19-related myocarditis is thought to be a combination of direct viral injury and cardiac damage due to the host's immune response. COVID-19 myocarditis diagnosis should be guided by insights from previous coronavirus and other myocarditis experience. The clinical findings include changes in electrocardiogram and cardiac biomarkers, and impaired cardiac function. When cardiac magnetic resonance imaging is not feasible, cardiac computed tomographic angiography with delayed myocardial imaging may serve to exclude significant coronary artery disease and identify myocardial inflammatory patterns. Because many COVID-19 patients have cardiovascular comorbidities, myocardial infarction should be considered. If the diagnosis remains uncertain, an endomyocardial biopsy may help identify active cardiac infection through viral genome amplification and possibly refine the treatment risks of systemic immunosuppression. Arrhythmias are not uncommon in COVID-19 patients, but the pathophysiology is still speculative. Nevertheless, clinicians should be vigilant to provide prompt monitoring and treatment. The long-term impact of COVID-19 myocarditis, including the majority of mild cases, remains unknown.

Indexed as

BetacoronavirusArrhythmias, CardiacCoronavirus InfectionsCOVID-19HumansMyocarditisPandemicsPneumonia, ViralSARS-CoV-2ArrhythmiasCoronavirus disease 2019Endomyocardial biopsyFulminant myocarditisInterleukin 6SARS-CoV-2

Identifiers

PMID32387246
PMCPMC7199677
OpenAlexW3023630330

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.