ArticleThe Annals of thoracic surgery2020
The Evolving Burden of Drug Use Associated Infective Endocarditis in the United States.
Article in The Annals of thoracic surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 57 citations in OpenAlex.
- Review
- Tricuspid Valve Infective Endocarditis in People Who Inject Drugs: A Single-Center Retrospective Observational Study of Percutaneous Mechanical Aspiration and a Surgical Approach.Infectious disease reports · 2026Article
- Insurance Status and Quality of Care in Infective Endocarditis: A National Analysis of Disparities in Length of Stay, Discharge, and Mortality.Journal of clinical medicine · 2026Article
- Systemic Embolic Events in People Who Inject Drugs With Patent Foramen Ovale and Right-Sided Infective Endocarditis: A Systematic Review.Open forum infectious diseases · 2026Article
- A comprehensive review of state laws that govern the distribution and possession of drug use equipment in the United States.The International journal on drug policy · 2026Review
- "It Eats My Heart": Identifying Knowledge Gaps in Injection Drug-Related Endocarditis Among Hospitalized Patients.Substance use & addiction journal · 2026Article
- Trends in Surgery for Endocarditis: 15-Year Experience From a Statewide Quality Collaborative.Annals of thoracic surgery short reports · 2025Article
- Inpatient addiction care is associated with increased vaccinations, medication for opioid use disorder and naloxone prescribing among patients with infective endocarditis in a rural state.Addiction science & clinical practice · 2025Article
- Long-term outcomes of surgical repair versus replacement for tricuspid valve endocarditis - AInternational journal of cardiology. Heart & vasculature · 2025Article
- Infective endocarditis: it takes a team.European heart journal · 2025Review
- Comparison of Outcomes of Percutaneous Mechanical Aspiration vs Tricuspid Valve Surgery in Drug Use-Associated Endocarditis of the Tricuspid Valve.Open forum infectious diseases · 2025Article
- Exploring sex differences in infective endocarditis - a prospective, observational study from Western Norway.BMC cardiovascular disorders · 2025Observational
- Association of socioeconomic disadvantage with operative outcomes for infective endocarditis.PloS one · 2025Article
- The rising cost of infective endocarditis in West Virginia.Epidemiology and infection · 2024Article
- Substance Use and Outcomes of Left-Sided Valve Replacement in Patients With Infective Endocarditis.Annals of thoracic surgery short reports · 2024Article
- Article
- Infective Endocarditis in North Africa and the Middle East, 1990‒2019: Updates from the Global Burden of Disease Study 2019.Archives of Iranian medicine · 2024Article
- Strategies to Improve Patient-Centered Care for Drug Use-Associated Infective Endocarditis: JACC Focus Seminar 2/4.Journal of the American College of Cardiology · 2024Review
- Endocarditis, drug use and biological sex: A statewide analysis comparing sex differences in drug use-associated infective endocarditis with other drug-related harms.The International journal on drug policy · 2024Article
- Article
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Authors and funding
11 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundThe rise in the number of valve operations performed for infective endocarditis (IE) due to drug use is an important manifestation of the opioid epidemic. This study characterized national trends and outcomes of valve surgery for drug use-associated IE (DU-IE).
methodsAdults undergoing valve surgery for active IE in The Society of Thoracic Surgeons (STS) Adult Cardiac Surgery Database between July 2011 and June 2018 were stratified as DU-IE and non-DU-IE. Trends and clinical profiles were analyzed. Early outcomes were assessed. The association of DU-IE with outcomes was analyzed with multivariable regression, adjusting for STS Valve Risk model covariates.
resultsThere were 34,905 valve operations performed for IE, of which 33.7% were for DU-IE. DU-IE operations increased 2.7-fold during the study period. There was considerable regional variability in DU-IE operations, ranging from 28% to 58% of all IE surgeries in 2018, with highest rates observed in East South Central and South Atlantic regions. DU-IE patients were younger and had fewer cardiovascular comorbidities. Risk-adjusted major morbidity and in-hospital mortality were significantly higher in the DU-IE group. Redo valve procedures in DU-IE patients were associated with worse outcomes, compared with those receiving a first valve operation.
conclusionsOperations for DU-IE have increased sharply in the United States during the last several years, exhibiting substantial regional variability. DU-IE patients have unique clinical profiles, and worse risk-adjusted outcomes. This demonstrates the significant impact of the opioid epidemic on endocarditis surgeries and punctuates the urgent need for multidisciplinary regional and national efforts to reverse this trend.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.