ArticleCurrent biology : CB2020
Sites of Circadian Clock Neuron Plasticity Mediate Sensory Integration and Entrainment.
Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 62 citations in OpenAlex.
- Assessment of adult structural plasticity in Drosophila neurons.Open biology · 2026Article
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- A functional clock in only two dorsal clock neurons is sufficient to restore the basal circadian activity pattern ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Synaptic targets of circadian clock neurons influence core clock parameters.Science advances · 2025Article
- Neuropeptide dynamics coordinate layered plasticity mechanisms adaptingScience advances · 2025Article
- Temperature-dependent modulation of light-induced circadian responses in Drosophila melanogaster.The EMBO journal · 2025Article
- Sexually dimorphic and clock gene-specific effects of artificial light at night onProceedings. Biological sciences · 2025Article
- Photoperiodic plasticity of pigment-dispersing factor immunoreactive fibers projecting toward prothoracicotropic hormone neurons in flesh fly Sarcophaga similis larvae.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Circadian rhythms are more resilient to pacemaker neuron disruption in female Drosophila.PLoS biology · 2025Article
- Mutual coupling of neurons in the circadian master clock: What we can learn from fruit flies.Neurobiology of sleep and circadian rhythms · 2025Article
- Synaptic Targets of Circadian Clock Neurons Influence Core Clock Parameters.bioRxiv : the preprint server for biology · 2025Article
- The Drosophila circadian clock gene cycle controls the development of clock neurons.PLoS genetics · 2024Article
- Suprachiasmatic nucleus VIPergic fibers show a circadian rhythm of expansion and retraction.Current biology : CB · 2024Article
- Spatiotemporal changes in Netrin/Dscam1 signaling dictate axonal projection direction ineLife · 2024Article
- Neural mechanism of circadian clock-based photoperiodism in insects and snails.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- Shining Light in Mechanobiology: Optical Tweezers, Scissors, and Beyond.ACS photonics · 2024Review
- TARANIS Interacts with VRILLE and PDP1 to Modulate the Circadian Transcriptional Feedback Mechanism inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Glial control of sphingolipid levels sculpts diurnal remodeling in a circadian circuit.Neuron · 2022Article
- PHASE: An Open-Source Program for the Analysis ofJournal of biological rhythms · 2022Article
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10 authors at 5 institutions in 1 country.
Funding
Abstract
Networks of circadian timekeeping in the brain display marked daily changes in neuronal morphology. In Drosophila melanogaster, the striking daily structural remodeling of the dorsal medial termini of the small ventral lateral neurons has long been hypothesized to mediate endogenous circadian timekeeping. To test this model, we have specifically abrogated these sites of daily neuronal remodeling through the reprogramming of neural development and assessed the effects on circadian timekeeping and clock outputs. Remarkably, the loss of these sites has no measurable effects on endogenous circadian timekeeping or on any of the major output functions of the small ventral lateral neurons. Rather, their loss reduces sites of glutamatergic sensory neurotransmission that normally encodes naturalistic time cues from the environment. These results support an alternative model: structural plasticity in critical clock neurons is the basis for proper integration of light and temperature and gates sensory inputs into circadian clock neuron networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.