Evidence map›Paper›PMID 32386517›Full record

ArticleDiagnostic pathology2020

Role of hypoxia-related proteins in adenoid cystic carcinoma invasion.

Raíssa Pinheiro de Mendonça, Giordanna Pereira Chemelo, Geovanni Pereira Mitre, Dimitra Castelo Branco, Natacha Malu Miranda da Costa, Fabrício Mesquita Tuji, Maria Sueli da Silva Kataoka, Ricardo Alves Mesquita, Sérgio de Melo Alves Júnior, João de Jesus Viana Pinheiro

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostic pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. International journal of particle therapy · 2025
    Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Raíssa Pinheiro de MendonçaDepartment of Oral Pathology, School of Dentistry, Universidade Federal do Pará, Avenida Augusto Correa, 01, Belem, Para, 66075-110, Brazil.
Giordanna Pereira ChemeloDepartment of Oral Pathology, School of Dentistry, Universidade Federal do Pará, Avenida Augusto Correa, 01, Belem, Para, 66075-110, Brazil.
Geovanni Pereira MitreDepartment of Oral Pathology, School of Dentistry, Universidade Federal do Pará, Avenida Augusto Correa, 01, Belem, Para, 66075-110, Brazil.
Dimitra Castelo BrancoMultiprofessional Residency Program, Universidade Estadual do Pará, Rua do Una, 156, Belem, Para, 66050-540, Brazil.
Natacha Malu Miranda da CostaDepartment of Periodontology, School of Dentistry, Universidade de São Paulo, Avenida do Café, Subsetor Oeste, 11, Ribeirão Preto, São Paulo, 14040-904, Brazil.
Fabrício Mesquita TujiDepartment of Oral Radiology, School of Dentistry, Universidade Federal do Pará, Avenida Augusto Correa, 01, Belem, Para, 66075-110, Brazil.
Maria Sueli da Silva KataokaDepartment of Oral Pathology, School of Dentistry, Universidade Federal do Pará, Avenida Augusto Correa, 01, Belem, Para, 66075-110, Brazil.
Ricardo Alves MesquitaDepartment of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Sérgio de Melo Alves JúniorDepartment of Oral Pathology, School of Dentistry, Universidade Federal do Pará, Avenida Augusto Correa, 01, Belem, Para, 66075-110, Brazil.
João de Jesus Viana PinheiroDepartment of Oral Pathology, School of Dentistry, Universidade Federal do Pará, Avenida Augusto Correa, 01, Belem, Para, 66075-110, Brazil. radface@hotmail.com.ORCID http://orcid.org/0000-0002-6914-6441
Universidade Federal do Pará · BRUniversidade de São Paulo · BRUniversidade do Estado do Pará · BRUniversidade Federal de Minas Gerais · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 305793/2014-4 and 429423/2018-7
6 · The paper itself

Abstract

backgroundAmong cancers affecting the oral cavity, adenoid cystic carcinoma (ACC) is a relatively common malignant neoplasm. It has high rates of metastasis and recurrence and is associated with significant morbidity. During the progression of ACC, the oxygen concentration is reduced in specific areas of the tumour microenvironment, leading to intratumoural hypoxia. The expression of NOTCH1, a disintegrin and metalloproteinase 12 (ADAM-12), hypoxia-inducible factor 1 alpha (HIF-1α), and heparin-binding epidermal growth factor (HB-EGF) under hypoxic conditions has been implicated in invadopodia formation, tumour invasiveness, and metastasis. The aim of this study was to analyse the expression of these proteins to elucidate the mechanisms underlying ACC invasiveness.

methodsFifteen ACC samples and 10 normal-looking salivary gland (SG) samples were used to investigate the expression of these proteins by immunohistochemistry. Primary antibodies against NOTCH1, ADAM-12, HIF-1α, and HB-EGF were used.

resultsThe immunoexpression of all proteins was higher in ACC samples than in SG samples (p < 0.05).

conclusionsThere was increased expression of proteins associated with hypoxia and tumour invasiveness in ACC samples, which indicates a possible role of these proteins in the biological behaviour of this tumour.

Indexed as

AdultAgedCarcinoma, Adenoid CysticCell HypoxiaFemaleHumansMaleMiddle AgedSalivary Gland NeoplasmsTumor MicroenvironmentAdenoid cystic carcinomaCell hypoxiaImmunohistochemistryInvadopodia

Identifiers

PMID32386517
PMCPMC7210690
OpenAlexW3021893374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.