Evidence map›Paper›PMID 32386467›Full record

ArticleActa physiologica (Oxford, England)2020

The sodium channel Na

Gerard A Marchal, Arie O Verkerk, Rajiv A Mohan, Rianne Wolswinkel, Bastiaan J D Boukens, Carol Ann Remme

Open access · hybridAbstract read
In one paragraph

Article in Acta physiologica (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Regenerative therapy · 2026
    Article
  2. Genetic background determines the severity of age-dependent cardiac structural abnormalities and arrhythmia susceptibility in Scn5a-1798insD mice.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  3. SCN5A-1795insD founder variant: a unique Dutch experience spanning 7 decades.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2023
    Review
  4. Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  5. The sodium channel NaActa physiologica (Oxford, England) · 2020
    Article
  6. Mechanisms of Arrhythmias in the Brugada Syndrome.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

  • Commented on by
    Na2020
5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Gerard A MarchalDepartment of Experimental Cardiology, Amsterdam UMC (location Academic Medical Center), Amsterdam, the Netherlands.ORCID 0000-0002-7353-0235
Arie O VerkerkDepartment of Experimental Cardiology, Amsterdam UMC (location Academic Medical Center), Amsterdam, the Netherlands.
Rajiv A MohanDepartment of Experimental Cardiology, Amsterdam UMC (location Academic Medical Center), Amsterdam, the Netherlands.
Rianne WolswinkelDepartment of Experimental Cardiology, Amsterdam UMC (location Academic Medical Center), Amsterdam, the Netherlands.
Bastiaan J D BoukensDepartment of Medical Biology, Amsterdam UMC (location Academic Medical Center), Amsterdam, the Netherlands.
Carol Ann RemmeDepartment of Experimental Cardiology, Amsterdam UMC (location Academic Medical Center), Amsterdam, the Netherlands.ORCID 0000-0003-0095-0084
Amsterdam UMC Location University of Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe voltage-gated sodium channel Na

methodsInvolvement of Na

resultsIn WT embryos, tetrodotoxin did not affect cardiac activation at E9.5, but slowed activation at E10.5. Accordingly, patch-clamp measurements revealed that I

conclusionWe here demonstrate that Na

Indexed as

Myocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelAnimalsMiceSodiumNAV1.5 Voltage-Gated Sodium ChannelSodiumcardiac morphologydevelopmentembryonic lethalitynon-electrogenicSCN5Asodium current

Identifiers

PMID32386467
PMCPMC7539970
OpenAlexW3021801957

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.