Evidence map›Paper›PMID 32386352›Full record

ArticleMolecular nutrition & food research2020

Increasing Doses of Blueberry Polyphenols Alters Colonic Metabolism and Calcium Absorption in Ovariectomized Rats.

Dennis P Cladis, Hawi Debelo, Pamela J Lachcik, Mario G Ferruzzi, Connie M Weaver

Open access · greenAbstract read
In one paragraph

Article in Molecular nutrition & food research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Blueberry (Foods (Basel, Switzerland) · 2024
    Review
  6. Screening of MMolecules (Basel, Switzerland) · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. The Impact of Hempseed Consumption on Bone Parameters and Body Composition in Growing Female C57BL/6 Mice.International journal of environmental research and public health · 2022
    Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dennis P CladisDepartment of Food Science, Purdue University, 745 Agriculture Mall Dr, West Lafayette, IN, 47907, USA.
Hawi DebeloPlants for Human Health Institute, North Carolina State University, 600 Laureate Way, Kannapolis, NC, 28081, USA.
Pamela J LachcikDepartment of Nutrition Science, Purdue University, 700 W State St, West Lafayette, IN, 47907, USA.
Mario G FerruzziPlants for Human Health Institute, North Carolina State University, 600 Laureate Way, Kannapolis, NC, 28081, USA.
Connie M WeaverDepartment of Food Science, Purdue University, 745 Agriculture Mall Dr, West Lafayette, IN, 47907, USA.ORCID 0000-0002-5450-9609
Purdue University West Lafayette · USNorth Carolina State University · US

Funding

Berries and BonesR01AT008754 · NCCIH · PURDUE UNIVERSITY · PI FORMAN, MICHELE ROBIN · 2014 to 2018
$3.9M
NCCIH NIH HHS R01 AT008754
6 · The paper itself

Abstract

scopeBlueberries are rich sources of bioactive polyphenols that may provide health benefits when consumed regularly, leading to their increased marketing as dietary supplements. However, the metabolic changes associated with consuming concentrated doses of purified polyphenols, as may be present in dietary supplements, are unknown, especially when considering the colonic metabolites formed. This study aimed to evaluate the pharmacokinetics of high doses of purified blueberry polyphenols. METHODS AND

results5-month old, ovariectomized Sprague-Dawley rats are acutely dosed with purified blueberry polyphenols (0, 75, 350, and 1000 mg total polyphenols per kg body weight (bw)) and

conclusionThese results indicate that increased doses of blueberry polyphenols induce changes in intestinal phenolic metabolism and increase calcium absorption.

Indexed as

AnimalsBlueberry PlantsCalciumColonDietary SupplementsDose-Response Relationship, DrugFemaleFlavonoidsHippuratesIntestinal AbsorptionOvariectomyPhenolsPolyphenolsRats, Sprague-DawleyCalciumFlavonoidsHippurateshippuric acidPhenolsPolyphenolsblueberriescalcium absorptioncolonic metabolismpharmacokineticspolyphenols

Identifiers

PMID32386352
PMCPMC9558423
OpenAlexW3020876303

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.