ArticleProteomics2020
Comparison of Proteomic Assessment Methods in Multiple Cohort Studies.
Open access · bronzeAbstract readComparative Study
In one paragraph
Article in Proteomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 3 pooled it
10.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
121 citing papers in PubMed, 3 syntheses or guidelines pooled it, 175 citations in OpenAlex.
- Blood Plasma Proteome: A Meta-Analysis of the Results of Protein Quantification in Human Blood by Targeted Mass Spectrometry.International journal of molecular sciences · 2023Pooled it
- Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis.The Journal of clinical investigation · 2022Pooled it
- Achieving Precision Medicine in Allergic Disease: Progress and Challenges.Frontiers in immunology · 2021Pooled it
- Genome-wide analysis of 439 mass spectrometry-based proteomic profiles in a population of 15,035 Scottish individuals.Nature communications · 2026Article
- Protein Profiling Identifies Biomarkers for Predicting Disease Severity in Anti-NMDAR Encephalitis.International journal of molecular sciences · 2026Article
- Aptamer-Based Platforms for Human Aging Biomarkers: Multiplexed Proteomics, Biosensors and Translational Perspectives.International journal of molecular sciences · 2026Review
- Proteomic Signatures of 3-Year Progression From Impaired Fasting Glucose to Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study.Diabetes care · 2026Article
- Multi-Omics Integration in Stroke: Neuroinflammatory Endotypes, Immune Cell Crosstalk, and Precision Biomarker Discovery.International journal of molecular sciences · 2026Review
- Lipoprotein(a)-associated proteomic signature predicts cardiovascular disease in young adults.The Journal of clinical investigation · 2026Observational
- The Proteomic Profile of Adults With a Fontan Circulation.JACC. Advances · 2026Article
- Dissecting non-small cell lung cancer (NSCLC) with blood proteomics-from surgical to immunotherapeutic responses.NPJ precision oncology · 2026Article
- Machine learning cross-platform proteomic imputation enables protein quality scoring and replication of epidemiological associations.bioRxiv : the preprint server for biology · 2026Article
- Plasma von Willebrand Factor and ADAMTS13 Interact WithJournal of the American Heart Association · 2026Article
- Proteomic Risk Score for Prediction of Incident Hypertension.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Vascular-related proteomic signatures in COPD with suspected pulmonary hypertension as predictors of FEV₁ impairment.Respiratory research · 2026Article
- Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross-Platform Validation.Annals of clinical and translational neurology · 2026Article
- Cross-ancestry comparison of aptamer and antibody protein measures.Nature communications · 2026Article
- The role of suPAR and related proteins in kidney, heart diseases, and diabetes.The Journal of clinical investigation · 2026Review
- Discovery of novel biomarkers associated with myocardial fibrosis in chimpanzees (Frontiers in veterinary science · 2026Article
- Baseline stool TIMP-2 predicts strictures and penetrating disease progression in Crohn's patients.Frontiers in immunology · 2026Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors at 20 institutions in 3 countries.
Laura M RaffieldDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599.
Hong DangMarsico Lung Institute , University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599.
Katherine A PratteDivision of Pulmonary Medicine , Department of Medicine, National Jewish Health (NJH), Denver, CO, 80206.
Sean JacobsonDivision of Pulmonary Medicine , Department of Medicine, National Jewish Health (NJH), Denver, CO, 80206.
Lucas A GillenwaterDivision of Pulmonary Medicine , Department of Medicine, National Jewish Health (NJH), Denver, CO, 80206.
Elizabeth AmplefordDepartment of Internal Medicine, Section for Pulmonary, Critical Care, Allergic and Immunologic Diseases, School of Medicine, Wake Forest University, Winston-Salem, NC, 27157.
Igor BarjaktarevicUCLA Division of Pulmonary and Critical Care, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095.
Patricia BastaDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599.
Clary B ClishMetabolomics Platform, Broad Institute, MIT and Harvard, Cambridge, MA, 02142.
Alejandro P ComellasDepartment of Internal Medicine, University of Iowa, Iowa City, IA, 52242.
Elaine CornellDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, 05405.
Jeffrey L CurtisDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, 48109.
Claire DoerschukMarsico Lung Institute , University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599.
Peter DurdaDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, 05405.
Claire EmsonTranslational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZenenca, Gaithersburg, MD, 20878.
Christine M FreemanDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, 48109.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, 90502.
Annette T HastieDepartment of Internal Medicine, Section for Pulmonary, Critical Care, Allergic and Immunologic Diseases, School of Medicine, Wake Forest University, Winston-Salem, NC, 27157.
Gregory A HawkinsDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, 27517.
Julio HerreraProterixBio, LLC, Billerica, MA, 01821.
W Craig JohnsonDepartment of Biostatistics, University of Washington, Seattle, WA, 98195.
Wassim W LabakiDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, 48109.
Yongmei LiuDepartment of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC, 27517.
Brett MastersProterixBio, LLC, Billerica, MA, 01821.
Michael MillerProterixBio, LLC, Billerica, MA, 01821.
Victor E OrtegaDepartment of Internal Medicine, Section for Pulmonary, Critical Care, Allergic and Immunologic Diseases, School of Medicine, Wake Forest University, Winston-Salem, NC, 27157.
George PapanicolaouEpidemiology Branch, Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute, Bethesda, MD, 20892.
Stephen PetersDepartment of Internal Medicine, Section for Pulmonary, Critical Care, Allergic and Immunologic Diseases, School of Medicine, Wake Forest University, Winston-Salem, NC, 27157.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, 90502.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, 90502.
Paul AuerZilber School of Public Health, University of Wisconsin Milwaukee, Milwaukee, WI, 53201.
Alex P ReinerFred Hutchinson Cancer Research Center, Seattle, WA, 98109.
Russell P TracyDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, 05405.
Debby NgoDivision of Pulmonary, Sleep and Critical Care Medicine, Beth Israel Deaconess Medical Center, Boston, MA, 02215.
Robert E GersztenDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, 02215.
Wanda K O'NealMarsico Lung Institute , University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599.
Russell P BowlerDivision of Pulmonary Medicine , Department of Medicine, National Jewish Health (NJH), Denver, CO, 80206.
NHLBI Trans-Omics for Precision Medicine (TOPMed) ConsortiumDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599.
Wake Forest University · USUniversity of Colorado Denver · USProterixBio (United States) · USUniversity of North Carolina at Chapel Hill · USUniversity of Vermont · USBeth Israel Deaconess Medical Center · USLung Institute · USMichigan Medicine · USUCLA Medical Center · USAstraZeneca (Finland) · FIBroad Institute · USCancer Research And Biostatistics · USFred Hutch Cancer Center · USHarbor–UCLA Medical Center · USMilwaukee Health Department · USNational Heart Lung and Blood Institute · USUniversity of California, Los Angeles · USUniversity of Iowa · USUniversity of Michigan–Ann Arbor · USUniversity of Virginia Health System · US
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MGenetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MTranslational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6MPulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6MSPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7MPULMONARY CELLULAR AND MOLECULAR BIOLOGY TRAININGT32HL007749 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Robert Pickett Dickson · 1993 to 2026
$19.9MCSRD VA I01 CX000911NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHGRI NIH HHS U54 HG003067NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL132320NHLBI NIH HHS R01 HL132947NHLBI NIH HHS R01 HL133870NHLBI NIH HHS R01 HL137995NHLBI NIH HHS T32 HL007749NHLBI NIH HHS T32 HL129982NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL137880NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK063491NIEHS NIH HHS P30 ES005605VA Merit Review I01 CX000911
Abstract
Novel proteomics platforms, such as the aptamer-based SOMAscan platform, can quantify large numbers of proteins efficiently and cost-effectively and are rapidly growing in popularity. However, comparisons to conventional immunoassays remain underexplored, leaving investigators unsure when cross-assay comparisons are appropriate. The correlation of results from immunoassays with relative protein quantification is explored by SOMAscan. For 63 proteins assessed in two chronic obstructive pulmonary disease (COPD) cohorts, subpopulations and intermediate outcome measures in COPD Study (SPIROMICS), and COPDGene, using myriad rules based medicine multiplex immunoassays and SOMAscan, Spearman correlation coefficients range from -0.13 to 0.97, with a median correlation coefficient of ≈0.5 and consistent results across cohorts. A similar range is observed for immunoassays in the population-based Multi-Ethnic Study of Atherosclerosis and for other assays in COPDGene and SPIROMICS. Comparisons of relative quantification from the antibody-based Olink platform and SOMAscan in a small cohort of myocardial infarction patients also show a wide correlation range. Finally, cis pQTL data, mass spectrometry aptamer confirmation, and other publicly available data are integrated to assess relationships with observed correlations. Correlation between proteomics assays shows a wide range and should be carefully considered when comparing and meta-analyzing proteomics data across assays and studies.
Indexed as
AdultAgedAged, 80 and overCohort StudiesFemaleHumansImmunoassayMaleMiddle AgedMyocardial InfarctionProteomeProteomicsPulmonary Disease, Chronic ObstructiveSmokersProteomeantibody microarraysbiomarkersmultiplexings
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.