Evidence map›Paper›PMID 32386321›Full record

ArticleThe Journal of infectious diseases2020

Lineage-Specific Expansion of Plasmodium falciparum Parasites With pfhrp2 Deletion in the Greater Mekong Subregion.

Justin Gibbons, Junling Qin, Pallavi Malla, Zenglei Wang, Awtum Brashear, Chengqi Wang, Jun Miao, John H Adams, Kami Kim, Rays Jiang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Review
  3. Local variability inMalariaWorld journal · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Justin GibbonsCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA.
Junling QinDepartment of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Pallavi MallaDepartment of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Zenglei WangThe National Health Commission Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Beijing Union Medical College, Beijing, China.
Awtum BrashearDepartment of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Chengqi WangCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA.
Jun MiaoCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA.
John H AdamsCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA.
Kami KimCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA.
Rays JiangCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA.
Liwang CuiCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA.

Funding

Southeast Asia Malaria Research CenterU19AI089672 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CUI, LIWANG · 2010 to 2023
$28.9M
NIAID NIH HHS U19 AI089672
6 · The paper itself

Abstract

Deletion of the pfhrp2 gene in Plasmodium falciparum can lead to false-negative rapid diagnostic test (RDT) results, constituting a major challenge for evidence-based malaria treatment. Here we analyzed the whole genome sequences of 138 P. falciparum clinical samples collected from the China-Myanmar boarder for pfhrp2 and pfhrp3 gene deletions. We found pfhrp2 and pfhrp3 deletions in 9.4% and 3.6% of samples, respectively, with no samples harboring deletions of both genes. The pfhrp2 deletions showed 2 distinct breakpoints, representing 2 different chromosomal deletion events. A phylogenetic analysis performed using genome-wide single-nucleotide polymorphisms revealed that the 2 pfhrp2 breakpoint groups as well as all the pfhrp3-negative parasites formed separate clades, suggesting they might have resulted from clonal expansion of pfhrp2- and pfhrp3-negative parasites. These findings highlight the need for urgent surveys to determine the prevalence of pfhrp2-negative parasites causing false-negative RDT results and a plan for switching of RDTs pending the survey results.

Indexed as

Antigens, ProtozoanChinaFalse Negative ReactionsGene DeletionGenome, ProtozoanHumansMalaria, FalciparumMyanmarPhylogenyPlasmodium falciparumPolymerase Chain ReactionPolymorphism, Single NucleotidePrevalenceProtozoan ProteinsSequence AlignmentAntigens, ProtozoanHRP-2 antigen, Plasmodium falciparumProtozoan Proteinsclonal expansiongenomepfhrp2 deletionPlasmodium falciparumSoutheast Asia

Identifiers

PMID32386321
PMCPMC7529045

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.