Evidence map›Paper›PMID 32386318›Full record

ArticleThe Journal of infectious diseases2020

High-Throughput Screening of Kawasaki Disease Sera for Antiviral Antibodies.

Daniel Quiat, Tomasz Kula, Chisato Shimizu, John T Kanegaye, Adriana H Tremoulet, Zachary Pitkowsky, MaryBeth Son, Jane W Newburger, Stephen J Elledge, Jane C Burns

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. The etiologies of Kawasaki disease.The Journal of clinical investigation · 2024
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Daniel QuiatDepartment of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA.
Tomasz KulaDepartment of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Chisato ShimizuDepartment of Pediatrics, University of California, San Diego, La Jolla, California, USA.
John T KanegayeRady Children's Hospital San Diego, San Diego, California, USA.
Adriana H TremouletDepartment of Pediatrics, University of California, San Diego, La Jolla, California, USA.
Zachary PitkowskyDepartment of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA.
MaryBeth SonDepartment of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Jane W NewburgerDepartment of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA.
Stephen J ElledgeDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Jane C BurnsDepartment of Pediatrics, University of California, San Diego, La Jolla, California, USA.
Boston Children's Hospital · USUniversity of California San Diego · USBrigham and Women's Hospital · USHarvard University · USRady Children's Hospital-San Diego · US

Funding

RESEARCH METHODS IN PEDIATRICS HEART DISEASET32HL007572 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI Sarah D DE FERRANTI, Jane W. Newburger · 1985 to 2026
$13.0M
NHLBI NIH HHS T32 HL007572
6 · The paper itself

Abstract

Clinical features of Kawasaki disease (KD) display overlap with common pediatric viral illnesses, leading some to hypothesize that a viral infection is the inciting event for KD. To investigate viral infection history in KD patients, we performed comprehensive serological profiling using a high-throughput phage immunoprecipitation sequencing assay covering the complete reference protein sequences of known viruses with human tropism. KD and matched febrile control sera did not demonstrate differences in antiviral antibody profiles. We conclude that in the acute and subacute phases of disease, KD patients do not exhibit serologic evidence of exposure to known viruses that differs from controls.

Indexed as

Antibodies, ViralAntiviral AgentsBacteriophagesChild, PreschoolFemaleHigh-Throughput Screening AssaysHumansImmunoglobulin GInfantMaleMucocutaneous Lymph Node SyndromeAntibodies, ViralAntiviral AgentsImmunoglobulin GantibodyKawasaki diseasevirus

Identifiers

PMID32386318
PMCPMC8171798
OpenAlexW3021108178

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.