ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020
Biomarkers Associated with Physical Resilience After Hip Fracture.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Short- and long-term prognostic factors associated with functional recovery in elderly patients with hip fracture: A systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Pooled it
- Better Mental Health and Fewer Depressive Symptoms Are Associated With Greater Psychological Resilience After Hip Fracture.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Trial
- Providing insight in resilience and recovery by using fatigability and its development over time in older adults after hip fracture surgery.European geriatric medicine · 2026Article
- Examining the relevance of gait speed resiliencies to different stressors: the ARIC Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Presurgical immune biomarkers associated with pain intensity and pain interference recovery after total knee arthroplasty: findings from the PRIME-KNEE study.medRxiv : the preprint server for health sciences · 2026Article
- Association between chronic inflammation and poorer long-term functional recovery post-hip fracture in and between men and women.JBMR plus · 2026Article
- Loss of molecular resilience as the ultimate outcome of aging biology.GeroScience · 2026Article
- Resilience and Intrinsic Capacity in Older Adults: A Review of Recent Literature.Journal of clinical medicine · 2025Review
- From frailty to resilience: exploring adaptive capacity and reserve in older adults-a narrative review.Frontiers in aging · 2025Review
- Ageing and physical resilience after health stressors.Stress and health : journal of the International Society for the Investigation of Stress · 2023Article
- An overview of the resilience world: Proceedings of the American Geriatrics Society and National Institute on Aging State of Resilience Science Conference.Journal of the American Geriatrics Society · 2023Article
- Assessment of Physical Resilience Using Residual Methods and Its Association With Adverse Outcomes in Older Adults.Innovation in aging · 2023Article
- Physical Resilience Phenotype Trajectories in Incident Hemodialysis: Characterization and Mortality Risk Assessment.Kidney international reports · 2022Article
- Mechanism of CREB1 in cardiac function of rats with heart failure via regulating the microRNA-376a-3p/TRAF6 axis.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Article
- Rejuvenation of neutrophils and their extracellular vesicles is associated with enhanced aged fracture healing.Aging cell · 2022Article
- Development and psychometric evaluation of the Physical Resilience Instrument for Older Adults (PRIFOR).BMC geriatrics · 2022Article
- Resilience: Biological Basis and Clinical Significance - A Perspective Report from the International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force.The Journal of frailty & aging · 2022Article
- Editorial: Resilience And Successful Aging.The journal of nutrition, health & aging · 2022Article
- Editorial: Resilience and the Future.The Journal of frailty & aging · 2022Article
- A template for physical resilience research in older adults: Methods of the PRIME-KNEE study.Journal of the American Geriatrics Society · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
backgroundClinically similar older adults demonstrate variable responses to health stressors, heterogeneity attributable to differences in physical resilience. However, molecular mechanisms underlying physical resilience are unknown. We previously derived a measure of physical resilience after hip fracture-the expected recovery differential (ERD)-that captures the difference between actual recovery and predicted recovery. Starting with biomarkers associated with physical performance, morbidity, mortality, and hip fracture, we evaluated associations with the ERD to identify biomarkers of physical resilience after hip fracture.
methodsIn the Baltimore Hip Studies (N = 304) sera, we quantified biomarkers of inflammation (TNFR-I, TNFR-II, sVCAM-1, and IL-6), metabolic and mitochondrial function (non-esterified fatty acids, lactate, ketones, acylcarnitines, free amino acids, and IGF-1), and epigenetic dysregulation (circulating microRNAs). We used principal component analysis, canonical correlation, and least absolute shrinkage and selection operator regression (LASSO) to identify biomarker associations with better-than-expected recovery (greater ERD) after hip fracture.
resultsParticipants with greater ERD were more likely to be women and less disabled at baseline. The complete biomarker set explained 37% of the variance in ERD (p < .001) by canonical correlation. LASSO regression identified a biomarker subset that accounted for 27% of the total variance in the ERD and included a metabolic factor (aspartate/asparagine, C22, C5:1, lactate, glutamate/mine), TNFR-I, miR-376a-3p, and miR-16-5p.
conclusionsWe identified a set of biomarkers that explained 27% of the variance in ERD-a measure of physical resilience after hip fracture. These ERD-associated biomarkers may be useful in predicting physical resilience in older adults facing hip fracture and other acute health stressors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.