Evidence map›Paper›PMID 32385839›Full record

ArticleNeurotoxicity research2020

Pyrroloquinoline Quinine and LY294002 Changed Cell Cycle and Apoptosis by Regulating PI3K-AKT-GSK3β Pathway in SH-SY5Y Cells.

Hongyun Ji, Junxiang Ma, Li Chen, Tian Chen, Shixuan Zhang, Jiaxin Jia, Xin Yang, Caixia Guo, Zhongxin Xiao, Piye Niu

Abstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Dexmedetomidine Inhibits Gasdermin D-Induced PyroptosisFrontiers in cellular neuroscience · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Hongyun Ji *Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, 100069, China.
Junxiang Ma *Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, 100069, China.
Li ChenDepartment of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, 100069, China.
Tian ChenDepartment of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, 100069, China.
Shixuan ZhangDepartment of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, 100069, China.
Jiaxin JiaDepartment of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, 100069, China.
Xin YangDepartment of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, 100069, China.
Caixia GuoDepartment of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, 100069, China.
Zhongxin XiaoCentral Laboratory, Capital Medical University, Beijing, 100069, China.
Piye NiuDepartment of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, 100069, China. niupiye@ccmu.edu.cn.
Capital Medical University · CN

Funding

National Natural Science Funding of China No. 81973007,81673137,81172640
6 · The paper itself

Abstract

To verify the role of PI3K-AKT-GSK3β pathway during manganese (Mn)-induced cell death, apoptosis, related indicators were investigated. SH-SY5Y cells were directly exposed to different concentrations of MnCl

Indexed as

ApoptosisCell CycleCell Line, TumorChromonesEnzyme InhibitorsGlycogen Synthase Kinase 3 betaHumansManganeseMorpholinesNeuronsPhosphatidylinositol 3-KinasesPQQ CofactorProto-Oncogene Proteins c-aktTrace Elements2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneChromonesEnzyme InhibitorsGlycogen Synthase Kinase 3 betaManganeseMorpholinesPhosphatidylinositol 3-KinasesPQQ CofactorProto-Oncogene Proteins c-aktTrace ElementsApoptosisCell cycleLY294002ManganesePyrroloquinoline quinine

Identifiers

PMID32385839
OpenAlexW3021203440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.