Evidence map›Paper›PMID 32385825›Full record

ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2020

Variability in deceased donor care in Canada: a report of the Canada-DONATE cohort study.

Frédérick D'Aragon, Francois Lamontagne, Deborah Cook, Sonny Dhanani, Sean Keenan, Michaël Chassé, Shane English, Karen E A Burns, Anne Julie Frenette, Ian Ball and 13 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03114436 (Canada-DONATE), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03114436 completednot on this map

Canada-DONATE: National Observational Study of Clinical Practices in Deceased Organ Donation

TypeobservationalSponsorMcMaster UniversityRan2016 to 2018Enrolled622ConditionsDeceased Organ Donation, Critical Illness, TransplantationArmsObservational Data Collection
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 13 institutions in 1 country.

Frédérick D'AragonDepartment of Anesthesiology, Université de Sherbrooke, 2001, 12e Avenue Nord, Sherbrooke, QC, J1H 5N4, Canada. Frederick.DAragon@USherbrooke.ca.ORCID http://orcid.org/0000-0003-1323-0449
Francois LamontagneCentre de Recherche du Centre Hospitalier, Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Deborah CookDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Sonny DhananiDivision of Critical Care, Department of Pediatrics, Children's Hospital of Eastern, Ontario University of Ottawa, Ottawa, ON, Canada.
Sean KeenanDepartment of Critical Care, University of British Columbia, Vancouver, BC, Canada.
Michaël ChasséDepartment of Medicine (Critical Care), Université de Montreal, Montreal, QC, Canada.
Shane EnglishDepartment of Medicine, University of Ottawa, Ottawa, ON, Canada.
Karen E A BurnsInterdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada.
Anne Julie FrenettePharmacy faculty, Université de Montreal, Montreal, QC, Canada.
Ian BallDepartment of Medicine, Western University, London, ON, Canada.
John Gordon BoydDepartment of Medicine (Neurology), Queen's University, Kingston, ON, Canada.
Marie-Hélène MasseCentre de Recherche du Centre Hospitalier, Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Ruth BreauDepartment of Health Evidence & Impact, McMaster University, Hamilton, ON, Canada.
Aemal AkhtarDepartment of Health Evidence & Impact, McMaster University, Hamilton, ON, Canada.
Andreas KramerDepartment of Critical Care Medicine, University of Calgary, Calgary, AB, Canada.
Bram RochwergDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
François LauzierPopulation Health and Optimal Health Practice Research Unit, CHU de Québec-Université Laval Research Center, Quebec City, QC, Canada.
Demetrios James KutsogiannisDepartment of Critical Care Medicine, University of Alberta, Edmonton, AB, Canada.
Quazi IbrahimDepartment of Health Evidence & Impact, McMaster University, Hamilton, ON, Canada.
Lori HandDepartment of Health Evidence & Impact, McMaster University, Hamilton, ON, Canada.
Qi ZhouDepartment of Health Evidence & Impact, McMaster University, Hamilton, ON, Canada.
Maureen O MeadeDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Canadian Critical Care Trials Group and the Canadian Donation and Transplant Research Program
Impact · CAUniversité de Sherbrooke · CAUniversity of Ottawa · CACentre Hospitalier Universitaire de Sherbrooke · CAHôpital du Sacré-Cœur de Montréal · CAQueen's University · CASt. Michael's Hospital · CAThe Quebec Population Health Research Network · CAUniversité de Montréal · CAUniversity of Alberta · CAUniversity of British Columbia · CAUniversity of Calgary · CAWestern University · CA

Funding

CIHR FRN94829
6 · The paper itself

Abstract

purposeCanadian donor management practices have not been reported. Our aim was to inform clinicians and other stakeholders about the range of current practices.

methodsThis prospective observational cohort study enrolled consecutive, newly consented organ donors from August 1 2015 to July 31 2018 at 27 academic and five community adult intensive care units in British Columbia, Alberta, Ontario, and Quebec. Research staff prospectively recorded donor management data. Provincial organ donation organizations verified the organs donated. We formally compared practices across provinces.

resultsOver a median collection period of eight months, 622 potential donors were classified at baseline as having neurologic determination of death (NDD donors; n = 403) or circulatory death (DCD donors; n = 219). Among NDD donors, 85.6% underwent apnea testing (rarely with carbon dioxide insufflation), 33.2% underwent ancillary testing, and subsequent therapeutic hypothermia (34-35°C) was rare. Neurologic determination of death donors were more hemodynamically unstable with most having received vasopressin and norepinephrine infusions, with a large majority having received high-dose corticosteroids and intravenous thyroxine. Among DCD donors, 61.6% received corticosteroids, and 8.9% received thyroxine. Most donors did not receive lung-protective ventilation strategies. Invasive procedures after donation consent included bronchoscopy (71.7%), cardiac catheterization (NDD donors only; 21.3%), and blood transfusions (19.3%). Physicians ordered intravenous antemortem heparin for 94.8% of DCD donors. The cohort donated 1,629 organs resulting in 1,532 transplants. Case selection, death determinations, and hormone, nutrition and heparin practices all varied across provinces.

conclusionThese study findings highlight areas for knowledge translation and further clinical research. Interprovincial discrepancies will likely pose unique challenges to national randomized trials.

trial registrationwww.clinicaltrials.gov (NCT03114436); registered 10 April, 2017.

Indexed as

Tissue DonorsAdultBritish ColumbiaHumansOntarioProspective StudiesTissue and Organ Procurement

Identifiers

PMID32385825
OpenAlexW3022990450

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.