Evidence map›Paper›PMID 32385773›Full record

ArticleMolecular biology reports2020

Deciphering insights of novel recombinant tmTNFα in cell growth inhibition.

Srirupa Bhattacharyya, Siddhartha Sankar Ghosh

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Srirupa BhattacharyyaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India.
Siddhartha Sankar GhoshDepartment of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India. sghosh@iitg.ac.in.ORCID http://orcid.org/0000-0002-7121-5610
Indian Institute of Technology Guwahati · IN

Funding

Department of Biotechnology , Ministry of Science and Technology BT/PR13560/COE/34/44/2015
6 · The paper itself

Abstract

Soluble TNFα, a member of TNF superfamily attributes dual roles in apoptosis and cell proliferation whereas its precursor transmembrane TNFα (tmTNFα) has potential for tumor reduction without initiating proliferation. In this perspective, we recombinantly expressed functional tmTNFα and explored its potential in cell growth inhibition. While structural characterizations of purified tmTNFα revealed integrity of the protein, cell viability assays demonstrated significant antiproliferative effect on HepG2 (IC

Indexed as

ApoptosisCaspasesCell Line, TumorCell ProliferationCell SurvivalG1 Phase Cell Cycle CheckpointsG2 Phase Cell Cycle CheckpointsHeLa CellsHep G2 CellsHumansMembrane Potential, MitochondrialProtein PrecursorsRecombinant ProteinsTumor Necrosis Factor-alphaTumor Necrosis FactorsCaspasesProtein PrecursorsRecombinant ProteinsTumor Necrosis Factor-alphatumor necrosis factor precursorTumor Necrosis FactorsAnti-cell proliferationApoptosisProtein therapyRecombinant tmTNFα

Identifiers

PMID32385773
OpenAlexW3023460606

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.