ArticleSurgical endoscopy2021
Poly-4-hydroxybutyrate (Phasix™) mesh onlay in complex abdominal wall repair.
Article in Surgical endoscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- The use of poly-4-hydroxybutyrate (P4HB, Phasix™) mesh in ventral hernia repair: a systematic review and meta-analysis.Hernia : the journal of hernias and abdominal wall surgery · 2024Pooled it
- Early and late outcomes of component separation with transversus abdominis release with mesh augmentation versus primary suturing for the management of abdominal dehiscence: a retrospective comparative study.World journal of emergency surgery : WJES · 2026Article
- Evaluating the Role of PhasixST™ Mesh in Laparoscopic Repair of Large Hiatal Hernias: Surgical Technique and Comprehensive Review of the Literature.Journal of clinical medicine · 2025Review
- Bio-resorbable poly-4-hydroxybutyrate (P4HB) mesh for abdominal wall reconstruction is effective in high-risk patients and contaminated abdomen.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Nanocomposite Biomaterials for Tissue-Engineered Hernia Repair: A Review of Recent Advances.Biomolecules · 2025Review
- Clinical outcomes of oncologic hernia repair using Poly-4-Hydroxybutyrate (P4HB) mesh.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Mesh exposure after ventral hernia repair with onlay biosynthetic mesh: a retrospective review of associated risk factors and management strategies.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- Long-term results with biosynthetic absorbable P4HB mesh in ventral abdominal wall repair: a multicentre analysis.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- Novel Material Optimization Strategies for Developing Upgraded Abdominal Meshes.International journal of molecular sciences · 2023Review
- Fully resorbable poly-4-hydroxybutyrate (P4HB) mesh for soft tissue repair and reconstruction: A scoping review.Frontiers in surgery · 2023Article
- Long-Term, Prospective, Multicenter Study of Poly-4-Hydroxybutyrate Mesh (Phasix Mesh) for Hernia Repair in Cohort at Risk for Complication: 60-Month Follow-Up.Journal of the American College of Surgeons · 2022Article
- Shifting the Goalpost in Ventral Hernia Care: 5-year Outcomes after Ventral Hernia Repair with Poly-4-hydroxybutyrate Mesh.Hernia : the journal of hernias and abdominal wall surgery · 2022Article
- Clinical outcomes of open abdominal wall reconstruction with the use of a polypropylene reinforced tissue matrix: a multicenter retrospective study.Hernia : the journal of hernias and abdominal wall surgery · 2022Article
- New Insights into the Application of 3D-Printing Technology in Hernia Repair.Materials (Basel, Switzerland) · 2021Review
- Abdominal wall reconstruction with biosynthetic absorbable mesh after infected prosthesis explantation: single stage is better than two-stage approach of chronic mesh infection.Hernia : the journal of hernias and abdominal wall surgery · 2021Article
- Slowly absorbable mesh in contaminated incisional hernia repair: results of a French multicenter study.Hernia : the journal of hernias and abdominal wall surgery · 2021Article
- An evaluation of clinical and quality of life outcomes after ventral hernia repair with poly-4-hydroxybutyrate mesh.Hernia : the journal of hernias and abdominal wall surgery · 2021Article
- Evaluation of a Novel Absorbable Mesh in a Porcine Model of Abdominal Wall Repair.Plastic and reconstructive surgery. Global open · 2021Article
- Biosynthetic Resorbable Prosthesis is Useful in Single-Stage Management of Chronic Mesh Infection After Abdominal Wall Hernia Repair.World journal of surgery · 2021Article
- Prospective, multicenter study of P4HB (Phasix™) mesh for hernia repair in cohort at risk for complications: 3-Year follow-up.Annals of medicine and surgery (2012) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPoly-4-hydroxybutyric acid (P4HB, Phasix™) is a biosynthetic polymer that degrades by hydrolysis that can be woven into a mesh for use in soft tissue reinforcement. Herein, we describe our initial experience performing complex abdominal wall repair (CAWR) utilizing component separation and P4HB mesh as onlay reinforcement.
methodsAll patients undergoing CAWR between June 2014 and May 2017 were followed prospectively for postoperative outcomes. Only those patients who underwent components separation with primary repair of the fascial edges followed by onlay of P4HB mesh were included in this study.
results105 patients (52 male, 53 female; mean age 59.2 years, range 22-84) met inclusion criteria. Mean BMI was 29.1 (range 16-48); 52% patients had prior attempted hernia repair, most with multiple medical comorbidities (71% of patients with ASA 3 or greater). 30% of cases were not clean at the time of repair (CDC class 2 or greater). Median follow-up was 36 months (range 9-63). Eighteen patients (17%) developed a hernia recurrence ranging from 2 to 36 months postoperatively. Five (5%) patients developed a localized superficial infection treated with antibiotics, three (2.8%) required re-operation for non-healing wounds, and six (6%) patients developed seroma.
conclusionsThese data demonstrate a relatively low rate of hernia recurrence, seroma, and other common complications of CAWR in a highly morbid patient population. Importantly, the rate of mesh infection was low and no patients required complete mesh removal, even when placed into a contaminated or infected surgical field.
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