ReviewCurrent hypertension reports2020
The Emerging Role of Gut Dysbiosis in Cardio-metabolic Risk Factors for Heart Failure.
Review in Current hypertension reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Trimethylamine N-Oxide in Heart Failure: A Meta-Analysis of Prognostic Value.Frontiers in cardiovascular medicine · 2022Pooled it
- Early diagnostic biomarkers for acute myocardial infarction unveiled by metabolomics, Mendelian randomization, and machine learning.Molecular biomedicine · 2026Article
- Fast graph convolutional models incorporating matrix factorization for predicting microbe-disease associations.Scientific reports · 2025Article
- Gut-heart axis: cardiac remodeling and heart failure in the context of inflammatory bowel disease and dysbiosis.American journal of physiology. Gastrointestinal and liver physiology · 2025Review
- Association between post-stroke cognitive impairment and gut microbiota in patients with ischemic stroke.Scientific reports · 2025Article
- Gut Microbiota in Heart Failure-The Role of Inflammation.Biomedicines · 2025Review
- Short-Chain Fatty Acids and Their Metabolic Interactions in Heart Failure.Biomedicines · 2025Review
- The Mediterranean Diet, Its Microbiome Connections, and Cardiovascular Health: A Narrative Review.International journal of molecular sciences · 2024Review
- Article
- Therapeutic applications of gut microbes in cardiometabolic diseases: current state and perspectives.Applied microbiology and biotechnology · 2024Review
- Polyphenols and Cardiometabolic Health: Knowledge and Concern among Romanian People.Nutrients · 2023Article
- Gut microbiota in various childhood disorders: Implication and indications.World journal of gastroenterology · 2022Review
- Sequence meets function-microbiota and cardiovascular disease.Cardiovascular research · 2022Review
- Knowledge Mapping of the Links Between the Gut Microbiota and Heart Failure: A Scientometric Investigation (2006-2021).Frontiers in cardiovascular medicine · 2022Article
- The Influence of Gut Microbiota on the Cardiovascular System Under Conditions of Obesity and Chronic Stress.Current hypertension reports · 2021Review
- Gut Microbiome and Precision Nutrition in Heart Failure: Hype or Hope?Current heart failure reports · 2021Review
- Diet-related gut microbial metabolites and sensing in hypertension.Journal of human hypertension · 2021Review
- The Correlation between Gut Microbiota and Serum Metabolomic in Elderly Patients with Chronic Heart Failure.Mediators of inflammation · 2021Article
- The Microbiome in Health and Disease from the Perspective of Modern Medicine and Ayurveda.Medicina (Kaunas, Lithuania) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewTo summarize the recent evidence that supports a role for the gut microbiota, microbiota-derived metabolites, and dysbiosis on cardiovascular risk factors, and to discuss the neuro-cardio-metabolic mechanisms that link gut microbiota and heart failure. RECENT
findingsThere is growing evidence that the gut microbiota communicates with and impacts the cardiovascular system, contributing to the development of heart failure once it becomes out of balance (i.e. gut dysbiosis). The exact mechanisms of how the gut microbiota influences cardiovascular outcomes are not fully understood, but immune dysregulation and disturbance of neuro-enteroendocrine hormones seem to be involved. The disturbances in the gut microbiota influence the progression of several risk factors for heart failure, including atherosclerosis, obesity, diabetes, kidney disease and hypertension. In turn, these conditions also act to regulate the gut microbiota through the deterioration of the integrity of the intestinal barrier and the release of neurotransmitters and gastrointestinal hormones. In normal and healthy physiological conditions, these interactions are homeostatic and tightly controlled. However, a combination of environmental exposures (e.g. antibiotics use and Western diet) and the host's intrinsic conditions (e.g. genetics and fluid status) can result in the breakdown of intestinal homeostasis and further progression of cardiovascular risk factors, which lead to the development of heart failure. Manipulation of the gut microbiota may have the potential to improve cardiovascular outcomes by ameliorating immune system dysregulation, enteroendocrine disruptions, and neurohormonal activation in patients with cardiovascular risk factors for heart failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.