ArticleEuropean child & adolescent psychiatry2021
Beneath the surface: hyper-connectivity between caudate and salience regions in ADHD fMRI at rest.
Article in European child & adolescent psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Distinct neurobiological alterations during hedonic experience of rewards in attention deficit hyperactivity disorder and autism spectrum disorder: Multimodal evidence from neuroimaging meta-analyses.Molecular psychiatry · 2026Pooled it
- Dopamine-Derived Oxidative Stress in Attention-Deficit/Hyperactivity Disorder: A Narrative Review of Molecular Mechanisms, Neural Circuitry, and Therapeutic Implications.Antioxidants (Basel, Switzerland) · 2026Review
- Disrupted Emergent Properties of the Brain in Schizophrenia: Insight From Integrated Information Decomposition of Resting State fMRI.Brain and behavior · 2026Article
- Maternal Thyroid Function During Pregnancy and Early Adolescent Regional Differences in Cerebral Gray Matter Morphology.The Journal of clinical endocrinology and metabolism · 2026Article
- Different brain functional network abnormalities between attention-deficit/hyperactivity disorder youth with and without familial risk for bipolar disorder.European child & adolescent psychiatry · 2024Article
- Association of Intrinsic Functional Connectivity between the Locus Coeruleus and Salience Network with Attentional Ability.Journal of cognitive neuroscience · 2023Article
- Centrality and interhemispheric coordination are related to different clinical/behavioral factors in attention deficit/hyperactivity disorder: a resting-state fMRI study.Brain imaging and behavior · 2022Article
- Seeking Overlapping Neuroanatomical Alterations between Dyslexia and Attention-Deficit/Hyperactivity Disorder: A Meta-Analytic Replication Study.Brain sciences · 2022Article
- Frontal corticostriatal functional connectivity reveals task positive and negative network dysregulation in relation to ADHD, sex, and inhibitory control.Developmental cognitive neuroscience · 2022Article
- Diagnostic model optimization method for ADHD based on brain network analysis of resting-state fMRI images and transfer learning neural network.Frontiers in human neuroscience · 2022Article
- Effects of prolonged methylphenidate treatment on amygdala reactivity and connectivity: a randomized controlled trial in stimulant treatment-naive, male participants with ADHD.Psychoradiology · 2021Article
- A Novel Knowledge Distillation-Based Feature Selection for the Classification of ADHD.Biomolecules · 2021Article
- Sex differences in attention deficit hyperactivity symptom severity and functional connectivity of the dorsal striatum in young adults.Neuroimage. Reports · 2021Article
- Diagnostic overlap and exploration of risk factors in child psychiatry.European child & adolescent psychiatry · 2021Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Attention-Deficit/Hyperactivity Disorder (ADHD) comprises disturbances in attention, emotional regulation, and reward-related processes. In spite of the active efforts in researching neurofunctional correlates of these symptoms, how the activity of subcortical regions-such as basal ganglia-is related to ADHD has yet to be clarified. More specifically, how age may influence the critical changes observed in functional dynamics from childhood to adulthood remains relatively unexplored. We hence selected five core subcortical regions (amygdala, caudate, putamen, pallidum and hippocampus) as regions of interest from the previous literature, measuring their whole-brain voxel-wise rsFC in a sample of 95 ADHD and 90 neurotypical children and adolescents aged from 7 to 18. The only subcortical structure showing significant differences in rsFC was the caudate nucleus. Specifically, we measured increased rsFC with anterior cingulate and right insula, two mesolimbic regions pertaining to the Salience Network. The degree of hyper-rsFC positively correlated with ADHD symptomatology, and showed different patterns of evolution in ADHD vs neurotypical subjects. Finally, the rsFC scores allowed a fair discrimination of the ADHD group (Area Under the Curve ≥ 0.7). These findings shed further light on the fundamental role covered by subcortical structures in ADHD pathogenesis and neurodevelopment, providing new evidence to fill the gap between neurofunctional and clinical expressions of ADHD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.