ArticleEuropean radiology2020
Speed of sound ultrasound: comparison with proton density fat fraction assessed with Dixon MRI for fat content quantification of the lower extremity.
Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 23 citations in OpenAlex.
- Comparison of Attenuation Imaging in the Rectus Femoris and Biceps Brachii Muscles with Multiecho Dixon-Based Fat Quantification and Ultrasound Echo Intensity.Diagnostics (Basel, Switzerland) · 2025Article
- The Biomechanics of Musculoskeletal Tissues during Activities of Daily Living: Dynamic Assessment Using Quantitative Transmission-Mode Ultrasound Techniques.Healthcare (Basel, Switzerland) · 2024Review
- Development of Continuous Assessment of Muscle Quality and Frailty in Older Patients Using Multiparametric Combinations of Ultrasound and Blood Biomarkers: Protocol for the ECOFRAIL Study.JMIR research protocols · 2024Article
- First-in-human diagnostic study of hepatic steatosis with computed ultrasound tomography in echo mode.Communications medicine · 2023Article
- Excluding Echo Shift Noise in Real-Time Pulse-Echo Speed-of-Sound Imaging.Sensors (Basel, Switzerland) · 2023Article
- Myosteatosis as a Shared Biomarker for Sarcopenia and Cachexia Using MRI and Ultrasound.Frontiers in rehabilitation sciences · 2022Article
- Speed of sound and shear wave speed for calf soft tissue composition and nonlinearity assessment.Quantitative imaging in medicine and surgery · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo compare speed of sound (SoS) ultrasound (US) of the calves with Dixon magnetic resonance imaging (MRI) for fat content quantification. MATERIALS AND
methodsThe study was approved by the local ethics committee. Fifty calf muscles of 35 women (age range 22-81 years) prospectively underwent an US and subsequent MRI (Dixon sequence) examination as well as body weight and impedance fat measurements. SoS (in m/s) was calculated positioning a reflector on the opposite side of a conventional US machine probe with the calf in between. Fiducial nitroglycerin markers were placed on the calf at the reflector and US probe end positions for later registration of the US sonification volumetric section. An automatic segmentation algorithm separated MRI adipose tissue, muscle and bone regions. MRI fat fraction of the entire leg slice (total) and intramuscular and adipose tissue fat fraction were calculated and correlation analysis and correlation coefficient comparison were performed.
resultsMedian SoS demonstrated a very strong (r = - 0.83 (95% CI - 0.90; - 0.72); p < 0.001) correlation with MRI total fat fraction, a strong (r = - 0.61 (95% CI - 0.76; - 0.40); p < 0.001) correlation with MRI adipose tissue fat fraction and a moderate (r = - 0.54 (95% CI - 0.71; - 0.31); p < 0.001) correlation with MRI intramuscular fat fraction. Impedance body fat percentage correlated strongly with SoS (r = - 0.72 (95% CI - 0.85; - 0.51); p < 0.001) and MRI total fat fraction (r = 0.61 (95% CI 0.34; 0.78); p < 0.001). For electrical impedance, significantly lower correlations (p = 0.033) were found for MRI total fat fraction compared with SoS.
conclusionsCorrelations of SoS with Dixon MRI fat fraction measurements were very strong to moderate. KEY POINTS: • Correlations of speed of sound with Dixon MRI fat fraction measurements of the same body location were very strong to moderate. • Speed of sound measurements showed a high repeatability. • Speed of sound provides a sufficient discrimination range for fat fraction estimates.
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