ArticleJournal of molecular evolution2020
Evolutionary Processes and Biophysical Mechanisms: Revisiting Why Evolved Proteins Are Marginally Stable.
Article in Journal of molecular evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The Borderlands of Foldability: Lessons from Simplified Proteins.Trends in chemistry · 2026Article
- How Binding Affinity and Binding Specificity Map to Sequence Space.Journal of molecular evolution · 2026Article
- Unexplored regions of the protein sequence-structure map revealed at scale by a library of foldtuned language models.bioRxiv : the preprint server for biology · 2025Article
- Temporal Quantitative Proteomic and Phosphoproteomic Profiling of SH-SY5Y and IMR-32 Neuroblastoma Cells during All-International journal of molecular sciences · 2024Article
- Protein Stability─Analysis of Heat and Cold Denaturation without and with Unfolding Models.The journal of physical chemistry. B · 2023Article
- Is Protein Folding a Thermodynamically Unfavorable, Active, Energy-Dependent Process?International journal of molecular sciences · 2022Review
- About the Protein Space Vastness.The protein journal · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evolved proteins observed in natural organisms are found to be only marginally stable. Several mechanistic hypotheses have been presented to date to explain this observation. One idea that has been put forward is that active selection prevents proteins from becoming too stable to enable proper function. A second idea is that marginal stability reflects the point of mutation-selection-drift balance, where it is mutational pressure that generates marginal stability. A third idea explored in this issue of Journal of Molecular Evolution is that a physical limit prevents the evolution of more stable proteins rather than an evolutionary process. While the first two notions are based upon specific evolutionary processes, discussion here is aimed at reconciling evolutionary processes with the physics of protein folding, drawing upon the ideas that have been presented.
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Registered trials
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