ArticleScientific reports2020
Structural equation modeling for investigating multi-trait genetic architecture of udder health in dairy cattle.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 31 citations in OpenAlex.
- Associations Between Feeding Management Practices Across Lactation and Goat Milk Composition in Semi-Intensive Systems: A Structural Equation Modeling Approach.Animals : an open access journal from MDPI · 2026Article
- Genome-wide association study of the reproductive, body size, and carcass-related latent and directly measured traits in admixed beef heifers.Frontiers in genetics · 2026Article
- Using Structural Equation Models to Interpret Genome-Wide Association Studies for Morphological and Productive Traits in Soybean [Plants (Basel, Switzerland) · 2025Article
- Revealing host genome-microbiome networks underlying feed efficiency in dairy cows.Scientific reports · 2024Article
- Quantitative omnigenic model discovers interpretable genome-wide associations.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Mendelian randomization analysis of 34,497 German Holstein cows to infer causal associations between milk production and health traits.Genetics, selection, evolution : GSE · 2024Article
- Genome-Wide Analysis of Milk Production Traits and Selection Signatures in Serbian Holstein-Friesian Cattle.Animals : an open access journal from MDPI · 2024Article
- Structural equation models to infer relationships between energy-related blood metabolites and milk daily energy output in Holstein cows.Journal of animal science · 2024Article
- Inferring causal structures of gut microbiota diversity and feed efficiency traits in poultry using Bayesian learning and genomic structural equation models.Journal of animal science · 2023Article
- An evaluation of homeostatic plasticity for ecosystems using an analytical data science approach.Computational and structural biotechnology journal · 2023Review
- Fifty years of structural equation modeling: A history of generalization, unification, and diffusion.Social science research · 2022Article
- Composition of the ileum microbiota is a mediator between the host genome and phosphorus utilization and other efficiency traits in Japanese quail (Coturnix japonica).Genetics, selection, evolution : GSE · 2022Article
- Prediction of fresh and ripened cheese yield using detailed milk composition and udder health indicators from individual Brown Swiss cows.Frontiers in veterinary science · 2022Article
- Genomic structural equation modelling provides a whole-system approach for the future crop breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Multitrait GWAS to connect disease variants and biological mechanisms.PLoS genetics · 2021Article
- Genome Wide Association Study of Beef Traits in Local Alpine Breed Reveals the Diversity of the Pathways Involved and the Role of Time Stratification.Frontiers in genetics · 2021Article
- Perspectives on Applications of Hierarchical Gene-To-Phenotype (G2P) Maps to Capture Non-stationary Effects of Alleles in Genomic Prediction.Frontiers in plant science · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mastitis is one of the most prevalent and costly diseases in dairy cattle. It results in changes in milk composition and quality which are indicators of udder inflammation in absence of clinical signs. We applied structural equation modeling (SEM) - GWAS aiming to explore interrelated dependency relationships among phenotypes related to udder health, including milk yield (MY), somatic cell score (SCS), lactose (%, LACT), pH and non-casein N (NCN, % of total milk N), in a cohort of 1,158 Brown Swiss cows. The phenotypic network inferred via the Hill-Climbing algorithm was used to estimate SEM parameters. Integration of multi-trait models-GWAS and SEM-GWAS identified six significant SNPs for SCS, and quantified the contribution of MY and LACT acting as mediator traits to total SNP effects. Functional analyses revealed that overrepresented pathways were often shared among traits and were consistent with biological knowledge (e.g., membrane transport activity for pH and MY or Wnt signaling for SCS and NCN). In summary, SEM-GWAS offered new insights on the relationships among udder health phenotypes and on the path of SNP effects, providing useful information for genetic improvement and management strategies in dairy cattle.
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