ArticleCommunications biology2020
Timekeeping in the hindbrain: a multi-oscillatory circadian centre in the mouse dorsal vagal complex.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Meal timing entrains circadian rhythms in the dorsal vagal complex, a brainstem satiety centre.PLoS biology · 2026Article
- The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026Review
- Gut microbiota, circadian rhythms and their interactions: implications for the pathogenesis and treatment of depression.Annals of medicine · 2025Review
- Cholecystokinin receptor expression and signaling remain constant across time of day in rat vagal afferent neurons.American journal of physiology. Cell physiology · 2025Article
- Brain circadian clocks timing the 24h rhythms of behavior.Npj biological timing and sleep · 2025Review
- Research progress on the correlation between biological rhythms and the blood-brain barrier after ischemic stroke.Frontiers in neurology · 2025Review
- Principles of synaptic encoding of brainstem circadian rhythms.Experimental physiology · 2024Review
- Brain access of incretins and incretin receptor agonists to their central targets relevant for appetite suppression and weight loss.American journal of physiology. Endocrinology and metabolism · 2024Review
- Whole-genome sequencing provides novel insights into the evolutionary history and genetic adaptation of reindeer populations in northern Eurasia.Scientific reports · 2023Article
- Circadian regulation of glutamate release pathways shapes synaptic throughput in the brainstem nucleus of the solitary tract (NTS).The Journal of physiology · 2023Article
- A new phase model of the spatiotemporal relationships between three circadian oscillators in the brainstem.Scientific reports · 2023Article
- Racing and Pacing in the Reward System: A Multi-Clock Circadian Control Over Dopaminergic Signalling.Frontiers in physiology · 2022Article
- Ticking and talking in the brainstem satiety centre: Circadian timekeeping and interactions in the diet-sensitive clock of the dorsal vagal complex.Frontiers in physiology · 2022Article
- Chrono-communication and cardiometabolic health: The intrinsic relationship and therapeutic nutritional promises.Frontiers in endocrinology · 2022Review
- The role of sleep state and time of day in modulating breathing in epilepsy: implications for sudden unexpected death in epilepsy.Frontiers in neural circuits · 2022Review
- Daily coordination of orexinergic gating in the rat superior colliculus-Implications for intrinsic clock activities in the visual system.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Timed daily exercise remodels circadian rhythms in mice.Communications biology · 2021Article
- High-fat feeding disrupts daily eating behavior rhythms in obesity-prone but not in obesity-resistant male inbred mouse strains.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Phasic Neuronal Firing in the Rodent Nucleus of the Solitary TractFrontiers in physiology · 2021Article
- Circadian actions of orexins on the retinorecipient lateral geniculate complex in rat.The Journal of physiology · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Metabolic and cardiovascular processes controlled by the hindbrain exhibit 24 h rhythms, but the extent to which the hindbrain possesses endogenous circadian timekeeping is unresolved. Here we provide compelling evidence that genetic, neuronal, and vascular activities of the brainstem's dorsal vagal complex are subject to intrinsic circadian control with a crucial role for the connection between its components in regulating their rhythmic properties. Robust 24 h variation in clock gene expression in vivo and neuronal firing ex vivo were observed in the area postrema (AP) and nucleus of the solitary tract (NTS), together with enhanced nocturnal responsiveness to metabolic cues. Unexpectedly, we also find functional and molecular evidence for increased penetration of blood borne molecules into the NTS at night. Our findings reveal that the hindbrain houses a local network complex of neuronal and non-neuronal autonomous circadian oscillators, with clear implications for understanding local temporal control of physiology in the brainstem.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.