ArticleNature communications2020
Chromosome-level assembly of the horseshoe crab genome provides insights into its genome evolution.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 96 citations in OpenAlex.
- Pax6 homologs are required for patterning both visual systems of the daddy-longlegs Phalangium opilio.Molecular biology and evolution · 2026Article
- Big Spider, Big Genome: Chromosome-Level Genome of a North American Tarantula (Aphonopelma marxi) and Comparative Genomics Across 300 Million Years of Spider Evolution.Genome biology and evolution · 2026Article
- Germline de novo mutation rate of the highly heterozygous amphioxus genome.Molecular biology and evolution · 2026Article
- Transcriptome Analysis Revealed the Copper Ion Uptake by Oocystis borgei from Offshore Polluted Water.Marine biotechnology (New York, N.Y.) · 2025Article
- Gene and Genome Duplication in Spiders.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Review
- How Did Evolution Halve Genome Size During an Oceanic Island Colonization?Molecular biology and evolution · 2025Article
- The genome of a sea spider corroborates a shared Hox cluster motif in arthropods with a reduced posterior tagma.BMC biology · 2025Article
- Whole Genome Duplication in the Genomics Era: The Hidden Gems in Invertebrates?Genome biology and evolution · 2025Review
- The chromosome-level genome provides insights into the adaptive evolution of the visual system in Oratosquilla oratoria.BMC biology · 2025Article
- Genome Assembly of a Living Fossil, the Atlantic Horseshoe Crab Limulus polyphemus, Reveals Lineage-Specific Whole-Genome Duplications, Transposable Element-Based Centromeres, and a ZW Sex Chromosome System.Molecular biology and evolution · 2025Article
- An ancient whole-genome duplication in barnacles contributes to their diversification and intertidal sessile life adaptation.Journal of advanced research · 2024Article
- Topological structures and syntenic conservation in sea anemone genomes.Nature communications · 2023Article
- Evolution of the Spider Homeobox Gene Repertoire by Tandem and Whole Genome Duplication.Molecular biology and evolution · 2023Article
- A Chromosome-Level Reference Genome for the Black-Legged Kittiwake (Rissa tridactyla), a Declining Circumpolar Seabird.Genome biology and evolution · 2023Article
- Dual Functions of labial Resolve the Hox Logic of Chelicerate Head Segments.Molecular biology and evolution · 2023Article
- An improved assembly of the "Cascade" hop (Horticulture research · 2023Article
- Transcriptomic Signature of Horseshoe CrabCurrent issues in molecular biology · 2022Article
- Eggs to long-legs: embryonic staging of the harvestman Phalangium opilio (Opiliones), an emerging model arachnid.Frontiers in zoology · 2022Article
- Assessing species coverage and assembly quality of rapidly accumulating sequenced genomes.GigaScience · 2022Article
- Conservation and Divergence ofInternational journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolutionary history of horseshoe crabs, spanning approximately 500 million years, is characterized by remarkable morphological stasis and a low species diversity with only four extant species. Here we report a chromosome-level genome assembly for the mangrove horseshoe crab (Carcinoscorpius rotundicauda) using PacBio reads and Hi-C data. The assembly spans 1.67 Gb with contig N50 of 7.8 Mb and 98% of the genome assigned to 16 chromosomes. The genome contains five Hox clusters with 34 Hox genes, the highest number reported in any invertebrate. Detailed analysis of the genome provides evidence that suggests three rounds of whole-genome duplication (WGD), raising questions about the relationship between WGD and species radiation. Several gene families, particularly those involved in innate immunity, have undergone extensive tandem duplication. These expanded gene families may be important components of the innate immune system of horseshoe crabs, whose amebocyte lysate is a sensitive agent for detecting endotoxin contamination.
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