ArticleInternational journal of oral science2020
Characteristics of oral methicillin-resistant Staphylococcus epidermidis isolated from dental plaque.
Article in International journal of oral science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- A human gut metagenome-assembled genome catalogue spanning 41 countries supports genome-scale metabolic models.Nature microbiology · 2026Pooled it
- Global prevalence of macrolide-resistantFrontiers in microbiology · 2025Pooled it
- Gram-positive oral bacteria as reservoirs of transferable antimicrobial resistance genes in dentistry.Journal of conservative dentistry and endodontics · 2026Article
- Isolation and characterization of broad-rangeMicrobiology (Reading, England) · 2026Article
- In Vitro Evaluation of Ethanolic Medicinal Plant Extracts from the Aseer Region Against Selected Cultured Oral Bacterial Isolates from Healthy Volunteers.Microorganisms · 2026Article
- Risk factors for the emergence of multidrug-resistant bacteria in patients with head and neck infections: a retrospective analysis.Frontiers in oral health · 2026Article
- Curcumin Internalization in Streptococcus mutans Biofilms: A Confocal Microscopy Analysis.Journal of biophotonics · 2025Article
- Enterobacterales abundance in oral cancer patients and elevated clindamycin resistance rates in head and neck infections at a Hungarian Tertiary Hospital.Annals of clinical microbiology and antimicrobials · 2025Article
- Cordycepin affects Streptococcus mutans biofilm and interferes with its metabolism.BMC oral health · 2025Article
- Prevalence, Antibiotic Resistance Pattern, and Molecular Characteristics ofJournal of tropical medicine · 2025Article
- Functional promiscuity of small multidrug resistance transporters from Staphylococcus aureus, Pseudomonas aeruginosa, and Francisella tularensis.Molecular microbiology · 2024Article
- Antimicrobial Resistance Profiles andClinical, cosmetic and investigational dermatology · 2024Article
- Antimicrobial resistance and virulence of subgingival staphylococci isolated from periodontal health and diseases.Scientific reports · 2023Article
- Inhibitory effects of simeprevir onZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Association of exogenous factors with molecular epidemiology ofSaudi journal of biological sciences · 2023Article
- Fish Epidermal Mucus as a Source of Diverse Therapeutical Compounds.International journal of peptide research and therapeutics · 2023Review
- AhrC Negatively Regulates Streptococcus mutans Arginine Biosynthesis.Microbiology spectrum · 2022Article
- The Composition and Functional Capacities of Saliva Microbiota Differ Between Children With Low and High Sweet Treat Consumption.Frontiers in nutrition · 2022Article
- Analysis of Plant Origin Antibiotics against Oral Bacterial Infections Using In Vitro and In Silico Techniques and Characterization of Active Constituents.Antibiotics (Basel, Switzerland) · 2021Article
- Acetylation of glucosyltransferases regulates Streptococcus mutans biofilm formation and virulence.PLoS pathogens · 2021Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The oral microbial community is widely regarded as a latent reservoir of antibiotic resistance genes. This study assessed the molecular epidemiology, susceptibility profile, and resistance mechanisms of 35 methicillin-resistant Staphylococcus epidermidis (MRSE) strains isolated from the dental plaque of a healthy human population. Broth microdilution minimum inhibitory concentrations (MICs) revealed that all the isolates were nonsusceptible to oxacillin and penicillin G. Most of them were also resistant to trimethoprim (65.7%) and erythromycin (54.3%). The resistance to multiple antibiotics was found to be largely due to the acquisition of plasmid-borne genes. The mecA and dfrA genes were found in all the isolates, mostly dfrG (80%), aacA-aphD (20%), aadD (28.6%), aphA3 (22.9%), msrA (5.7%), and the ermC gene (14.3%). Classical mutational mechanisms found in these isolates were mainly efflux pumps such as qacA (31.4%), qacC (25.7%), tetK (17.1%), and norA (8.6%). Multilocus sequence type analysis revealed that sequence type 59 (ST59) strains comprised 71.43% of the typed isolates, and the eBURST algorithm clustered STs into the clonal complex 2-II(CC2-II). The staphyloccoccal cassette chromosome mec (SCCmec) type results showed that 25 (71.43%) were assigned to type IV. Moreover, 88.66% of the isolates were found to harbor six or more biofilm-associated genes. The aap, atlE, embp, sdrF, and IS256 genes were detected in all 35 isolates. This research demonstrates that biofilm-positive multiple-antibiotic-resistant ST59-SCCmec IV S. epidermidis strains exist in the dental plaque of healthy people and may be a potential risk for the transmission of antibiotic resistance.
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